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Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance

The development of next-generation antimalarials that are efficacious against the human liver and asexual blood stages is recognized as one of the world’s most pressing public health challenges. In recent years, aminoacyl-tRNA synthetases, including prolyl-tRNA synthetase, have emerged as attractive...

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Detalles Bibliográficos
Autores principales:	Tye, Mark A., Payne, N. Connor, Johansson, Catrine, Singh, Kritika, Santos, Sofia A., Fagbami, Lọla, Pant, Akansha, Sylvester, Kayla, Luth, Madeline R., Marques, Sofia, Whitman, Malcolm, Mota, Maria M., Winzeler, Elizabeth A., Lukens, Amanda K., Derbyshire, Emily R., Oppermann, Udo, Wirth, Dyann F., Mazitschek, Ralph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403976/ https://www.ncbi.nlm.nih.gov/pubmed/36008486 http://dx.doi.org/10.1038/s41467-022-32630-4

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