Cargando…

Benzodioxole grafted spirooxindole pyrrolidinyl derivatives: synthesis, characterization, molecular docking and anti-diabetic activity

A highly stereoselective, three-component method has been developed to synthesize pyrrolidine and pyrrolizidine containing spirooxindole derivatives. The interaction between the dipolarophile α,β-unsaturated carbonyl compounds and the dipole azomethine ylide formed in situ by the reaction of 1,2-dic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nivetha, Narayanasamy, Martiz, Reshma Mary, Patil, Shashank M., Ramu, Ramith, Sreenivasa, Swamy, Velmathi, Sivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404121/ https://www.ncbi.nlm.nih.gov/pubmed/36128541 http://dx.doi.org/10.1039/d2ra04452h

Ejemplares similares

Iodide/H(2)O(2) Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles
por: Gao, Yu-Ting, et al.
Publicado: (2018)

Phyto-Computational Intervention of Diabetes Mellitus at Multiple Stages Using Isoeugenol from Ocimum tenuiflorum: A Combination of Pharmacokinetics and Molecular Modelling Approaches
por: Martiz, Reshma Mary, et al.
Publicado: (2022)

Integrated network pharmacology and molecular modeling approach for the discovery of novel potential MAPK3 inhibitors from whole green jackfruit flour targeting obesity-linked diabetes mellitus
por: Maradesha, Tejaswini, et al.
Publicado: (2023)

Dipolarophile-Controlled Regioselective 1,3-Dipolar Cycloaddition: A Switchable Divergent Access to Functionalized N-Fused Pyrrolidinyl Spirooxindoles
por: Wang, Yongchao, et al.
Publicado: (2023)

Discovery of Novel Coumarin Derivatives as Potential Dual Inhibitors against α-Glucosidase and α-Amylase for the Management of Post-Prandial Hyperglycemia via Molecular Modelling Approaches
por: Patil, Shashank M., et al.
Publicado: (2022)

Discovery of novel benzophenone integrated derivatives as anti-Alzheimer’s agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach
por: Martiz, Reshma Mary, et al.
Publicado: (2022)

Defining the Role of Isoeugenol from Ocimum tenuiflorum against Diabetes Mellitus-Linked Alzheimer’s Disease through Network Pharmacology and Computational Methods
por: Martiz, Reshma Mary, et al.
Publicado: (2022)

The COVID-19 Vaccine Saga: A Perspective
por: Patil, Shashank M, et al.
Publicado: (2021)

A Perspective on the Effective Conduction of Functional-based Coaching Program on Diabetic Indonesian Communities
por: Ramu, Ramith, et al.
Publicado: (2021)

Synthesis and Photophysical, Electrochemical, and DFT Studies of Piperidyl and Pyrrolidinyl Chalcones
por: Baig, Humera, et al.
Publicado: (2023)

Transition metal-catalyzed synthesis of spirooxindoles
por: Saranya, P. V., et al.
Publicado: (2021)

Comparative molecular docking and simulation analysis of molnupiravir and remdesivir with SARS-CoV-2 RNA dependent RNA polymerase (RdRp)
por: Patil, Shashank M, et al.
Publicado: (2021)

Computer-Aided Screening of Phytoconstituents from Ocimum tenuiflorum against Diabetes Mellitus Targeting DPP4 Inhibition: A Combination of Molecular Docking, Molecular Dynamics, and Pharmacokinetics Approaches
por: Sajal, Harshit, et al.
Publicado: (2022)

Competent synthesis of biaryl analogs via asymmetric Suzuki–Miyaura cross-coupling for the development of anti-inflammatory and analgesic agents
por: Gurupadaswamy, H. D., et al.
Publicado: (2022)

Inhibition of carbohydrate hydrolyzing enzymes by a potential probiotic Levilactobacillus brevis RAMULAB49 isolated from fermented Ananas comosus
por: Martiz, Reshma Mary, et al.
Publicado: (2023)

Azomethine Ylides—Versatile Synthons for Pyrrolidinyl-Heterocyclic Compounds
por: Panda, Siva S., et al.
Publicado: (2023)

Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines
por: Badillo, Joseph J., et al.
Publicado: (2014)

Conformational Control of Dual Emission by Pyrrolidinyl PNA–DNA Hybrids
por: Sezi, Sabrina, et al.
Publicado: (2012)

Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies
por: Sahu, Nawal Kishore, et al.
Publicado: (2023)

A systematic review on ethnopharmacology, phytochemistry and pharmacological aspects of Thymus vulgaris Linn.
por: Patil, Shashank M., et al.
Publicado: (2021)

Synthesis and optical properties of pyrrolidinyl peptide nucleic acid carrying a clicked Nile red label
por: Yotapan, Nattawut, et al.
Publicado: (2014)

Design and Synthesis of Pyrrolidinyl Ferrocene-Containing Ligands and Their Application in Highly Enantioselective Rhodium-Catalyzed Olefin Hydrogenation
por: Li, Xin, et al.
Publicado: (2022)

Asymmetric Synthesis of Spirooxindoles via Nucleophilic Epoxidation Promoted by Bifunctional Organocatalysts
por: Miceli, Martina, et al.
Publicado: (2018)

Naphthalimide based smart sensor for CN(−)/Fe(3+) and H(2)S. Synthesis and application in RAW264.7 cells and zebrafish imaging
por: Naha, Sanay, et al.
Publicado: (2020)

Electrochemical Synthesis of Fluorinated Orthoesters from 1,3‐Benzodioxoles
por: Röckl, Johannes L., et al.
Publicado: (2019)

Molecular docking, chemo-informatic properties, alpha-amylase, and lipase inhibition studies of benzodioxol derivatives
por: Hawash, Mohammed, et al.
Publicado: (2021)

Protocol to identify multiple protein targets and therapeutic compounds using an in silico polypharmacological approach
por: Simha N, Akshaya, et al.
Publicado: (2023)

Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold
por: Reed, Brian, et al.
Publicado: (2022)

An Efficient Synthesis of Oxygen-Bridged Spirooxindoles via Microwave-Promoted Multicomponent Reaction
por: Shi, Yaojing, et al.
Publicado: (2023)

Synthesis of spirooxindoles via formal acetylene insertion into a common palladacycle intermediate
por: Abel-Snape, Xavier, et al.
Publicado: (2023)

Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis
por: Azarnier, Shima Ghanbari, et al.
Publicado: (2022)

Pyrrolidinyl caffeamide against ischemia/reperfusion injury in cardiomyocytes through AMPK/AKT pathways
por: Lee, Shih-Yi, et al.
Publicado: (2015)

Synthesis and Evaluation of New Benzodioxole- Based Thiosemicarbazone Derivatives as Potential Antitumor Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2016)

Molecular docking and simulation analysis of the FimH protein with secondary metabolites from the Garcinia species
por: Badiger, Abhijeeth S, et al.
Publicado: (2022)

Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines
por: Rainoldi, Giulia, et al.
Publicado: (2017)

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization
por: Wu, Ting, et al.
Publicado: (2017)

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
por: Panda, Siva S., et al.
Publicado: (2023)

Inhibitory Effect of Polyphenols from the Whole Green Jackfruit Flour against α-Glucosidase, α-Amylase, Aldose Reductase and Glycation at Multiple Stages and Their Interaction: Inhibition Kinetics and Molecular Simulations
por: Maradesha, Tejaswini, et al.
Publicado: (2022)

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors
por: Barakat, Assem, et al.
Publicado: (2020)

Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents
por: Al-Majid, Abdullah Mohammed, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i3uia5cqn7qnguehqe2p2gk23o