Functional roles of ADP-ribosylation writers, readers and erasers

ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers. As an intricate and versatile PTM, ADP-ribosylation plays critical roles in various physiological and pathological processes. In this review, we...

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Detalles Bibliográficos
Autores principales: Li, Ping, Lei, Yushuang, Qi, Jia, Liu, Wanqin, Yao, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404506/
https://www.ncbi.nlm.nih.gov/pubmed/36035988
http://dx.doi.org/10.3389/fcell.2022.941356
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author Li, Ping
Lei, Yushuang
Qi, Jia
Liu, Wanqin
Yao, Kai
author_facet Li, Ping
Lei, Yushuang
Qi, Jia
Liu, Wanqin
Yao, Kai
author_sort Li, Ping
collection PubMed
description ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers. As an intricate and versatile PTM, ADP-ribosylation plays critical roles in various physiological and pathological processes. In this review, we discuss the major players involved in the ADP-ribosylation cycle, which may facilitate the investigation of the ADP-ribosylation function and contribute to the understanding and treatment of ADP-ribosylation associated disease.
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spelling pubmed-94045062022-08-26 Functional roles of ADP-ribosylation writers, readers and erasers Li, Ping Lei, Yushuang Qi, Jia Liu, Wanqin Yao, Kai Front Cell Dev Biol Cell and Developmental Biology ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers. As an intricate and versatile PTM, ADP-ribosylation plays critical roles in various physiological and pathological processes. In this review, we discuss the major players involved in the ADP-ribosylation cycle, which may facilitate the investigation of the ADP-ribosylation function and contribute to the understanding and treatment of ADP-ribosylation associated disease. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9404506/ /pubmed/36035988 http://dx.doi.org/10.3389/fcell.2022.941356 Text en Copyright © 2022 Li, Lei, Qi, Liu and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li, Ping
Lei, Yushuang
Qi, Jia
Liu, Wanqin
Yao, Kai
Functional roles of ADP-ribosylation writers, readers and erasers
title Functional roles of ADP-ribosylation writers, readers and erasers
title_full Functional roles of ADP-ribosylation writers, readers and erasers
title_fullStr Functional roles of ADP-ribosylation writers, readers and erasers
title_full_unstemmed Functional roles of ADP-ribosylation writers, readers and erasers
title_short Functional roles of ADP-ribosylation writers, readers and erasers
title_sort functional roles of adp-ribosylation writers, readers and erasers
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404506/
https://www.ncbi.nlm.nih.gov/pubmed/36035988
http://dx.doi.org/10.3389/fcell.2022.941356
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