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Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice

Estrogen agonist raloxifene is an FDA-approved treatment of osteoporosis in postmenopausal women, which may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that 1) aging and biological sex contribute to IVD degeneration by reducing estrogen...

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Detalles Bibliográficos
Autores principales:	Bhadouria, Neharika, Berman, Alycia G., Wallace, Joseph M., Holguin, Nilsson
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404526/ https://www.ncbi.nlm.nih.gov/pubmed/36032728 http://dx.doi.org/10.3389/fbioe.2022.924918

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