IKAROS and MENIN Coordinate Therapeutically Actionable Leukaemogenic Gene Expression in MLL-r Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) remains difficult to treat and requires new therapeutic approaches. Potent inhibitors of the chromatin-associated protein MENIN have recently entered human clinical trials, opening new therapeutic opportunities for some genetic subtypes of this disease. Using genome-sca...

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Detalles Bibliográficos
Autores principales: Aubrey, Brandon J., Cutler, Jevon A., Bourgeois, Wallace, Donovan, Katherine A., Gu, Shengqing, Hatton, Charlie, Perlee, Sarah, Perner, Florian, Rahnamoun, Homa, Theall, Alexandra C. P., Henrich, Jill A., Zhu, Qian, Nowak, Radosław P., Kim, Young Joon, Parvin, Salma, Cremer, Anjali, Olsen, Sarah Naomi, Eleuteri, Nicholas A., Pikman, Yana, McGeehan, Gerard M., Stegmaier, Kimberly, Letai, Anthony, Fischer, Eric S., Liu, X. Shirley, Armstrong, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404532/
https://www.ncbi.nlm.nih.gov/pubmed/35534777
http://dx.doi.org/10.1038/s43018-022-00366-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404532/
https://www.ncbi.nlm.nih.gov/pubmed/35534777
http://dx.doi.org/10.1038/s43018-022-00366-1

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