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Predictive factors contributing to prolonged recovery in patients after Fontan operation
BACKGROUND: Prolonged recovery is a severe issue in patients after Fontan operation. However, predictive factors related to this issue are not adequately evaluated. The present study aimed to investigate potential predictive factors which can predict Fontan postoperative recovery. METHODS: We retros...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404579/ https://www.ncbi.nlm.nih.gov/pubmed/36002809 http://dx.doi.org/10.1186/s12887-022-03537-2 |
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author | Song, Yixiao Wang, Liping Zhang, Mingjie Chen, Xi Pang, Yachang Liu, Jiaqi Xu, Zhuoming |
author_facet | Song, Yixiao Wang, Liping Zhang, Mingjie Chen, Xi Pang, Yachang Liu, Jiaqi Xu, Zhuoming |
author_sort | Song, Yixiao |
collection | PubMed |
description | BACKGROUND: Prolonged recovery is a severe issue in patients after Fontan operation. However, predictive factors related to this issue are not adequately evaluated. The present study aimed to investigate potential predictive factors which can predict Fontan postoperative recovery. METHODS: We retrospectively reviewed the perioperative medical records of patients with Fontan surgery between January 2015 and December 2018, and divided patients with > 75%ile cardiac intensive care unit stay into prolonged recovery group. The others were assigned to standard recovery group. Patients that died or underwent a Fontan takedown were excluded. Statistical analysis was performed to compare data difference of the two groups. RESULTS: 282/307 cases fulfilled the inclusion criteria. Seventy patients were considered in prolonged recovery and 212 patients were defined as standard recovery. Pre- and intra-operative data showed a higher incidence of heterotaxy syndrome, longer cardiopulmonary bypass and aortic cross-clamp time in the prolonged recovery group. Postoperative information analysis displayed that ventilation time, oxygen index after extubation, hemodynamic data, inotropic score (IS), drainage volume, volume resuscitation, pulmonary hypertension (PH) treatment, and surgical reintervention were significantly different between the two groups. Higher IS postoperatively, and PH treatment and higher fluid resuscitation within two days were independent predictive factors for prolonged recovery in our multivariate model. C-statistic model showed a high predictive ability in prolonged recovery by using the three factors. CONCLUSIONS: Ventilation time, higher IS in postoperative day, and PH treatment and higher fluid resuscitation within two days were independent risk factors and have a high predictability for Fontan prolonged recovery. |
format | Online Article Text |
id | pubmed-9404579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94045792022-08-26 Predictive factors contributing to prolonged recovery in patients after Fontan operation Song, Yixiao Wang, Liping Zhang, Mingjie Chen, Xi Pang, Yachang Liu, Jiaqi Xu, Zhuoming BMC Pediatr Research BACKGROUND: Prolonged recovery is a severe issue in patients after Fontan operation. However, predictive factors related to this issue are not adequately evaluated. The present study aimed to investigate potential predictive factors which can predict Fontan postoperative recovery. METHODS: We retrospectively reviewed the perioperative medical records of patients with Fontan surgery between January 2015 and December 2018, and divided patients with > 75%ile cardiac intensive care unit stay into prolonged recovery group. The others were assigned to standard recovery group. Patients that died or underwent a Fontan takedown were excluded. Statistical analysis was performed to compare data difference of the two groups. RESULTS: 282/307 cases fulfilled the inclusion criteria. Seventy patients were considered in prolonged recovery and 212 patients were defined as standard recovery. Pre- and intra-operative data showed a higher incidence of heterotaxy syndrome, longer cardiopulmonary bypass and aortic cross-clamp time in the prolonged recovery group. Postoperative information analysis displayed that ventilation time, oxygen index after extubation, hemodynamic data, inotropic score (IS), drainage volume, volume resuscitation, pulmonary hypertension (PH) treatment, and surgical reintervention were significantly different between the two groups. Higher IS postoperatively, and PH treatment and higher fluid resuscitation within two days were independent predictive factors for prolonged recovery in our multivariate model. C-statistic model showed a high predictive ability in prolonged recovery by using the three factors. CONCLUSIONS: Ventilation time, higher IS in postoperative day, and PH treatment and higher fluid resuscitation within two days were independent risk factors and have a high predictability for Fontan prolonged recovery. BioMed Central 2022-08-24 /pmc/articles/PMC9404579/ /pubmed/36002809 http://dx.doi.org/10.1186/s12887-022-03537-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Song, Yixiao Wang, Liping Zhang, Mingjie Chen, Xi Pang, Yachang Liu, Jiaqi Xu, Zhuoming Predictive factors contributing to prolonged recovery in patients after Fontan operation |
title | Predictive factors contributing to prolonged recovery in patients after Fontan operation |
title_full | Predictive factors contributing to prolonged recovery in patients after Fontan operation |
title_fullStr | Predictive factors contributing to prolonged recovery in patients after Fontan operation |
title_full_unstemmed | Predictive factors contributing to prolonged recovery in patients after Fontan operation |
title_short | Predictive factors contributing to prolonged recovery in patients after Fontan operation |
title_sort | predictive factors contributing to prolonged recovery in patients after fontan operation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404579/ https://www.ncbi.nlm.nih.gov/pubmed/36002809 http://dx.doi.org/10.1186/s12887-022-03537-2 |
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