Both T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SSc

BACKGROUND: Recently, a novel humanized mouse model for systemic sclerosis (SSc) was established by transferring peripheral blood mononuclear cells (PBMC) from patients with SSc to Rag2(−/−)Il2rg(−/−) immunodeficient mice. Here, we aimed to investigate the role of T and B cells in this humanized mou...

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Detalles Bibliográficos
Autores principales: Shu, Yaqing, Yue, Xiaoyang, Wax, Jacqueline, Kasper, Brigitte, Yin, Junping, Wang, Xiaoqing, Zhang, Liang, Ahmadi, Marjan, Heidecke, Harald, Müller, Antje, Lamprecht, Peter, Yu, Xinhua, Riemekasten, Gabriela, Petersen, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404611/
https://www.ncbi.nlm.nih.gov/pubmed/36008863
http://dx.doi.org/10.1186/s13075-022-02896-6

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