EphA4 targeting agents protect motor neurons from cell death induced by amyotrophic lateral sclerosis -astrocytes

Amyotrophic lateral sclerosis (ALS) is a degenerative disease that progressively destroys motor neurons (MNs). Earlier studies identified EphA4, a receptor tyrosine kinase, as a possible disease-modifying gene. The complex interplay between the EphA4 receptor and its ephrin ligands in motor neurons...

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Detalles Bibliográficos
Autores principales: Dennys, Cassandra, Baggio, Carlo, Rodrigo, Rochelle, Roussel, Florence, Kulinich, Anna, Heintzman, Sarah, Fox, Ashley, Kolb, Stephen J., Shaw, Pamela J., Ethell, Iryna M., Pellecchia, Maurizio, Meyer, Kathrin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404653/
https://www.ncbi.nlm.nih.gov/pubmed/36034213
http://dx.doi.org/10.1016/j.isci.2022.104877

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