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Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris. The material in the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404673/ https://www.ncbi.nlm.nih.gov/pubmed/33827375 http://dx.doi.org/10.1080/02656736.2021.1905189 |
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author | Xu, Zhen Hall, Timothy L. Vlaisavljevich, Eli Lee, Fred T. |
author_facet | Xu, Zhen Hall, Timothy L. Vlaisavljevich, Eli Lee, Fred T. |
author_sort | Xu, Zhen |
collection | PubMed |
description | Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris. The material in the histotripsy ablation zone is absorbed by the body within 1–2 months, leaving a minimal remnant scar. Histotripsy has also been shown to stimulate an immune response and induce abscopal effects in animal models, which may have positive implications for future cancer treatment. Histotripsy has been investigated for a wide range of applications in preclinical studies, including the treatment of cancer, neurological diseases, and cardiovascular diseases. Three human clinical trials have been undertaken using histotripsy for the treatment of benign prostatic hyperplasia, liver cancer, and calcified valve stenosis. This review provides a comprehensive overview of histotripsy covering the origin, mechanism, bioeffects, parameters, instruments, and the latest results on preclinical and human studies. |
format | Online Article Text |
id | pubmed-9404673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-94046732022-08-25 Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound Xu, Zhen Hall, Timothy L. Vlaisavljevich, Eli Lee, Fred T. Int J Hyperthermia Article Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris. The material in the histotripsy ablation zone is absorbed by the body within 1–2 months, leaving a minimal remnant scar. Histotripsy has also been shown to stimulate an immune response and induce abscopal effects in animal models, which may have positive implications for future cancer treatment. Histotripsy has been investigated for a wide range of applications in preclinical studies, including the treatment of cancer, neurological diseases, and cardiovascular diseases. Three human clinical trials have been undertaken using histotripsy for the treatment of benign prostatic hyperplasia, liver cancer, and calcified valve stenosis. This review provides a comprehensive overview of histotripsy covering the origin, mechanism, bioeffects, parameters, instruments, and the latest results on preclinical and human studies. 2021 /pmc/articles/PMC9404673/ /pubmed/33827375 http://dx.doi.org/10.1080/02656736.2021.1905189 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Xu, Zhen Hall, Timothy L. Vlaisavljevich, Eli Lee, Fred T. Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound |
title | Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound |
title_full | Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound |
title_fullStr | Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound |
title_full_unstemmed | Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound |
title_short | Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound |
title_sort | histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404673/ https://www.ncbi.nlm.nih.gov/pubmed/33827375 http://dx.doi.org/10.1080/02656736.2021.1905189 |
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