Cargando…

Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. In this context, tumor cells have an altered redox balance compared to normal cells, which can be targeted as an antitumoral therapy by ROS levels and by dec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Florido, Javier, Rodriguez-Santana, César, Martinez-Ruiz, Laura, López-Rodríguez, Alba, Acuña-Castroviejo, Darío, Rusanova, Iryna, Escames, Germaine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404709/ https://www.ncbi.nlm.nih.gov/pubmed/36009340 http://dx.doi.org/10.3390/antiox11081621

Ejemplares similares

Protective Effects of Melatonin on the Skin: Future Perspectives
por: Rusanova, Iryna, et al.
Publicado: (2019)

Role of Melatonin in Cancer: Effect on Clock Genes
por: Rodríguez-Santana, César, et al.
Publicado: (2023)

Chronodisruption and Loss of Melatonin Rhythm, Associated with Alterations in Daily Motor Activity and Mitochondrial Dynamics in Parkinsonian Zebrafish, Are Corrected by Melatonin Treatment
por: Aranda-Martínez, Paula, et al.
Publicado: (2023)

The Relationship between Clock Genes, Sirtuin 1, and Mitochondrial Activity in Head and Neck Squamous Cell Cancer: Effects of Melatonin Treatment
por: Rodríguez-Santana, César, et al.
Publicado: (2023)

Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport
por: Florido, Javier, et al.
Publicado: (2022)

Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function
por: Guerra-Librero, Ana, et al.
Publicado: (2021)

The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle
por: Sayed, Ramy KA, et al.
Publicado: (2021)

Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy
por: Fernández-Ortiz, Marisol, et al.
Publicado: (2022)

The Zebrafish, an Outstanding Model for Biomedical Research in the Field of Melatonin and Human Diseases
por: Aranda-Martínez, Paula, et al.
Publicado: (2022)

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy
por: Fernandez-Gil, Beatriz I., et al.
Publicado: (2019)

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage
por: Sayed, Ramy K. A., et al.
Publicado: (2021)

Oral Mucositis: Melatonin Gel an Effective New Treatment
por: Abdel Moneim, Ahmed Esmat, et al.
Publicado: (2017)

Role of c-miR-21, c-miR-126, Redox Status, and Inflammatory Conditions as Potential Predictors of Vascular Damage in T2DM Patients
por: López-Armas, Gabriela C., et al.
Publicado: (2022)

The Role of Mitochondria in Brain Aging and the Effects of Melatonin
por: Escames, Germaine, et al.
Publicado: (2010)

Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging
por: Sayed, Ramy K. A., et al.
Publicado: (2020)

Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans
por: Rusanova, Iryna, et al.
Publicado: (2018)

A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial
por: Rodríguez-Rubio, Miguel, et al.
Publicado: (2020)

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging
por: Fernández-Ortiz, Marisol, et al.
Publicado: (2020)

A phase II, single‐center, double‐blind, randomized placebo‐controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit
por: Mansilla‐Roselló, Alfonso, et al.
Publicado: (2022)

Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation
por: López-Armas, Gabriela, et al.
Publicado: (2016)

Melatonin protects rats from radiotherapy-induced small intestine toxicity
por: Fernández-Gil, Beatriz, et al.
Publicado: (2017)

Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases
por: Duisenbek, Ayauly, et al.
Publicado: (2023)

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases
por: López, Ana, et al.
Publicado: (2017)

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease
por: Barriocanal-Casado, Eliana, et al.
Publicado: (2019)

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis
por: Rodríguez-Hidalgo, María, et al.
Publicado: (2018)

Effect of 5-Azacitidine Treatment on Redox Status and Inflammatory Condition in MDS Patients
por: Montes, Paola, et al.
Publicado: (2022)

Melatonin in Antinociception: Its Therapeutic Applications
por: Srinivasan, Venkatramanujam, et al.
Publicado: (2012)

Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co‐expression network analysis
por: Liu, Qiong, et al.
Publicado: (2022)

BSCI-27. MELATONIN REDUCES MALIGNANCY OF BREAST CANCER BRAIN METASTATIC CELLS
por: Gil, Beatriz Fernandez, et al.
Publicado: (2019)

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3
por: Reiter, Russel J., et al.
Publicado: (2018)

The clinical heterogeneity of coenzyme Q(10) deficiency results from genotypic differences in the Coq9 gene
por: Luna-Sánchez, Marta, et al.
Publicado: (2015)

The NLRP3 inflammasome: contributions to inflammation-related diseases
por: Chen, Ying, et al.
Publicado: (2023)

The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice
por: Figueiro-Silva, Joana, et al.
Publicado: (2018)

Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?
por: Romero, Alejandro, et al.
Publicado: (2020)

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
por: Reiter, Russel J., et al.
Publicado: (2017)

β‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 (R239X) mice
por: Hidalgo‐Gutiérrez, Agustín, et al.
Publicado: (2018)

DDRE-33. MELATONIN AS A MASTER METABOLIC SWITCH FOR GLIOBLASTOMA
por: Fernandez-Gil, Beatriz Irene, et al.
Publicado: (2021)

Accumulation of Exogenous Amyloid-Beta Peptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin
por: Rosales-Corral, Sergio, et al.
Publicado: (2012)

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome
por: Luna‐Sánchez, Marta, et al.
Publicado: (2016)

Cellular and Biochemical Actions of Melatonin which Protect Against Free Radicals: Role in Neurodegenerative Disorders
por: Ortiz, Genaro G, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_523e035j7affjp0hci5j2ue5a2