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A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment

For centuries, the cannabis plant has been used as a source of food, fiber, and medicine. Recently, scientific interest in cannabis has increased considerably, as its bioactive compounds have shown promising potential in the treatment of numerous musculoskeletal and neurological diseases in humans....

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Autores principales: Licitra, Rosario, Marchese, Maria, Naef, Valentina, Ogi, Asahi, Martinelli, Marco, Kiferle, Claudia, Fronte, Baldassare, Santorelli, Filippo Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404760/
https://www.ncbi.nlm.nih.gov/pubmed/36009367
http://dx.doi.org/10.3390/biomedicines10081820
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author Licitra, Rosario
Marchese, Maria
Naef, Valentina
Ogi, Asahi
Martinelli, Marco
Kiferle, Claudia
Fronte, Baldassare
Santorelli, Filippo Maria
author_facet Licitra, Rosario
Marchese, Maria
Naef, Valentina
Ogi, Asahi
Martinelli, Marco
Kiferle, Claudia
Fronte, Baldassare
Santorelli, Filippo Maria
author_sort Licitra, Rosario
collection PubMed
description For centuries, the cannabis plant has been used as a source of food, fiber, and medicine. Recently, scientific interest in cannabis has increased considerably, as its bioactive compounds have shown promising potential in the treatment of numerous musculoskeletal and neurological diseases in humans. However, the mechanisms that underlie its possible effects on neurodevelopment and nervous-system functioning remain poorly understood and need to be further investigated. Although the bulk of research on cannabis and cannabinoids is based on in vitro or rodent models, the zebrafish has now emerged as a powerful in vivo model for drug-screening studies and translational research. We here review the available literature on the use of cannabis/cannabinoids in zebrafish, and particularly in zebrafish models of neurological disorders. A critical analysis suggests that zebrafish could serve as an experimental tool for testing the bioactivity of cannabinoids, and they could thus provide important insights into the safety and efficacy of different cannabis-extract-based products. The review showed that zebrafish exhibit similar behaviors to rodents following cannabinoid exposure. The authors stress the importance of analyzing the full spectrum of naturally occurring cannabinoids, rather than just the main ones, THC and CBD, and they offer some pointers on performing behavioral analysis in zebrafish.
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spelling pubmed-94047602022-08-26 A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment Licitra, Rosario Marchese, Maria Naef, Valentina Ogi, Asahi Martinelli, Marco Kiferle, Claudia Fronte, Baldassare Santorelli, Filippo Maria Biomedicines Systematic Review For centuries, the cannabis plant has been used as a source of food, fiber, and medicine. Recently, scientific interest in cannabis has increased considerably, as its bioactive compounds have shown promising potential in the treatment of numerous musculoskeletal and neurological diseases in humans. However, the mechanisms that underlie its possible effects on neurodevelopment and nervous-system functioning remain poorly understood and need to be further investigated. Although the bulk of research on cannabis and cannabinoids is based on in vitro or rodent models, the zebrafish has now emerged as a powerful in vivo model for drug-screening studies and translational research. We here review the available literature on the use of cannabis/cannabinoids in zebrafish, and particularly in zebrafish models of neurological disorders. A critical analysis suggests that zebrafish could serve as an experimental tool for testing the bioactivity of cannabinoids, and they could thus provide important insights into the safety and efficacy of different cannabis-extract-based products. The review showed that zebrafish exhibit similar behaviors to rodents following cannabinoid exposure. The authors stress the importance of analyzing the full spectrum of naturally occurring cannabinoids, rather than just the main ones, THC and CBD, and they offer some pointers on performing behavioral analysis in zebrafish. MDPI 2022-07-28 /pmc/articles/PMC9404760/ /pubmed/36009367 http://dx.doi.org/10.3390/biomedicines10081820 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Licitra, Rosario
Marchese, Maria
Naef, Valentina
Ogi, Asahi
Martinelli, Marco
Kiferle, Claudia
Fronte, Baldassare
Santorelli, Filippo Maria
A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
title A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
title_full A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
title_fullStr A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
title_full_unstemmed A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
title_short A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
title_sort review on the bioactivity of cannabinoids on zebrafish models: emphasis on neurodevelopment
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404760/
https://www.ncbi.nlm.nih.gov/pubmed/36009367
http://dx.doi.org/10.3390/biomedicines10081820
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