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The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin

Mycoplasma gallisepticum (Mg) is a highly contagious avian pathogen responsible for significant economic losses for the poultry industry. In some circumstances, antimicrobial treatment is useful to contain clinical signs of Mg infection in birds. However, antimicrobial resistance emergence is now co...

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Autores principales: Bottinelli, Marco, Gastaldelli, Michele, Picchi, Micaela, Dall’Ora, Arianna, Cristovao Borges, Lorena, Ramírez, Ana Sofía, Matucci, Andrea, Catania, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404793/
https://www.ncbi.nlm.nih.gov/pubmed/36009890
http://dx.doi.org/10.3390/antibiotics11081021
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author Bottinelli, Marco
Gastaldelli, Michele
Picchi, Micaela
Dall’Ora, Arianna
Cristovao Borges, Lorena
Ramírez, Ana Sofía
Matucci, Andrea
Catania, Salvatore
author_facet Bottinelli, Marco
Gastaldelli, Michele
Picchi, Micaela
Dall’Ora, Arianna
Cristovao Borges, Lorena
Ramírez, Ana Sofía
Matucci, Andrea
Catania, Salvatore
author_sort Bottinelli, Marco
collection PubMed
description Mycoplasma gallisepticum (Mg) is a highly contagious avian pathogen responsible for significant economic losses for the poultry industry. In some circumstances, antimicrobial treatment is useful to contain clinical signs of Mg infection in birds. However, antimicrobial resistance emergence is now common among animal pathogens, becoming a worldwide health concern. The collection of minimum inhibitory concentration (MIC) data is fundamental for an appropriate antimicrobial use and for fighting antimicrobial resistance emergence. However, MIC data can only be generated in specialized laboratories, and therefore they are not regularly available. MICs of 67 non-vaccine-derived Mg isolates collected in Italy between 2010 and 2020 were obtained. Although 79.1% of the Mg isolates showed enrofloxacin MICs ≥ 8 µg/mL, a statistically significant trend toward low MICs of erythromycin, tylosin, tilmicosin, spiramycin, tiamulin, and lincomycin was observed, indicating a comeback to susceptibility of Mg toward these drugs. Doxycycline proved to be slightly more effective than oxytetracycline. The present study shows that Mg changed its susceptibility toward many of the drugs most commonly used for its containment over a ten-year period.
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spelling pubmed-94047932022-08-26 The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin Bottinelli, Marco Gastaldelli, Michele Picchi, Micaela Dall’Ora, Arianna Cristovao Borges, Lorena Ramírez, Ana Sofía Matucci, Andrea Catania, Salvatore Antibiotics (Basel) Article Mycoplasma gallisepticum (Mg) is a highly contagious avian pathogen responsible for significant economic losses for the poultry industry. In some circumstances, antimicrobial treatment is useful to contain clinical signs of Mg infection in birds. However, antimicrobial resistance emergence is now common among animal pathogens, becoming a worldwide health concern. The collection of minimum inhibitory concentration (MIC) data is fundamental for an appropriate antimicrobial use and for fighting antimicrobial resistance emergence. However, MIC data can only be generated in specialized laboratories, and therefore they are not regularly available. MICs of 67 non-vaccine-derived Mg isolates collected in Italy between 2010 and 2020 were obtained. Although 79.1% of the Mg isolates showed enrofloxacin MICs ≥ 8 µg/mL, a statistically significant trend toward low MICs of erythromycin, tylosin, tilmicosin, spiramycin, tiamulin, and lincomycin was observed, indicating a comeback to susceptibility of Mg toward these drugs. Doxycycline proved to be slightly more effective than oxytetracycline. The present study shows that Mg changed its susceptibility toward many of the drugs most commonly used for its containment over a ten-year period. MDPI 2022-07-29 /pmc/articles/PMC9404793/ /pubmed/36009890 http://dx.doi.org/10.3390/antibiotics11081021 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bottinelli, Marco
Gastaldelli, Michele
Picchi, Micaela
Dall’Ora, Arianna
Cristovao Borges, Lorena
Ramírez, Ana Sofía
Matucci, Andrea
Catania, Salvatore
The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin
title The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin
title_full The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin
title_fullStr The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin
title_full_unstemmed The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin
title_short The Monitoring of Mycoplasma gallisepticum Minimum Inhibitory Concentrations during the Last Decade (2010–2020) Seems to Reveal a Comeback of Susceptibility to Macrolides, Tiamulin, and Lincomycin
title_sort monitoring of mycoplasma gallisepticum minimum inhibitory concentrations during the last decade (2010–2020) seems to reveal a comeback of susceptibility to macrolides, tiamulin, and lincomycin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404793/
https://www.ncbi.nlm.nih.gov/pubmed/36009890
http://dx.doi.org/10.3390/antibiotics11081021
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