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Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications

Implants are used to replace damaged biological structures in human body. Although stainless steel (SS) is a well-known implant material, corrosion of SS implants leads to the release of toxic metallic ions, which produce harmful effects in human body. To prevent material degradation and its harmful...

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Autores principales: Batool, Syeda Ammara, Liaquat, Ushna, Channa, Iftikhar Ahmad, Gilani, Sadaf Jamal, Makhdoom, Muhammad Atif, Yasir, Muhammad, Ashfaq, Jaweria, Jumah, May Nasser bin, Rehman, Muhammad Atiq ur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404864/
https://www.ncbi.nlm.nih.gov/pubmed/36004892
http://dx.doi.org/10.3390/bioengineering9080367
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author Batool, Syeda Ammara
Liaquat, Ushna
Channa, Iftikhar Ahmad
Gilani, Sadaf Jamal
Makhdoom, Muhammad Atif
Yasir, Muhammad
Ashfaq, Jaweria
Jumah, May Nasser bin
Rehman, Muhammad Atiq ur
author_facet Batool, Syeda Ammara
Liaquat, Ushna
Channa, Iftikhar Ahmad
Gilani, Sadaf Jamal
Makhdoom, Muhammad Atif
Yasir, Muhammad
Ashfaq, Jaweria
Jumah, May Nasser bin
Rehman, Muhammad Atiq ur
author_sort Batool, Syeda Ammara
collection PubMed
description Implants are used to replace damaged biological structures in human body. Although stainless steel (SS) is a well-known implant material, corrosion of SS implants leads to the release of toxic metallic ions, which produce harmful effects in human body. To prevent material degradation and its harmful repercussions, these implanted materials are subjected to biocompatible coatings. Polymeric coatings play a vital role in enhancing the mechanical and biological integrity of the implanted devices. Zein is a natural protein extracted from corn and is known to have good biocompatibility and biodegradability. In this study, zein/Ag-Sr doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were deposited on SS substrates via electrophoretic deposition (EPD) at different parameters. Ag and Sr ions were added to impart antibacterial and osteogenic properties to the coatings, respectively. In order to examine the surface morphology of coatings, optical microscopy and scanning electron microscopy (SEM) were performed. To analyze mechanical strength, a pencil scratch test, bend test, and corrosion and wear tests were conducted on zein/Ag-Sr doped MBGN coatings. The results show good adhesion strength, wettability, corrosion, and wear resistance for zein/Ag-Sr doped MBGN coatings as compared to bare SS substrate. Thus, good mechanical and biological properties were observed for zein/Ag-Sr doped MBGN coatings. Results suggested these zein/Ag-Sr MBGNs coatings have great potential in bone regeneration applications.
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spelling pubmed-94048642022-08-26 Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications Batool, Syeda Ammara Liaquat, Ushna Channa, Iftikhar Ahmad Gilani, Sadaf Jamal Makhdoom, Muhammad Atif Yasir, Muhammad Ashfaq, Jaweria Jumah, May Nasser bin Rehman, Muhammad Atiq ur Bioengineering (Basel) Article Implants are used to replace damaged biological structures in human body. Although stainless steel (SS) is a well-known implant material, corrosion of SS implants leads to the release of toxic metallic ions, which produce harmful effects in human body. To prevent material degradation and its harmful repercussions, these implanted materials are subjected to biocompatible coatings. Polymeric coatings play a vital role in enhancing the mechanical and biological integrity of the implanted devices. Zein is a natural protein extracted from corn and is known to have good biocompatibility and biodegradability. In this study, zein/Ag-Sr doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were deposited on SS substrates via electrophoretic deposition (EPD) at different parameters. Ag and Sr ions were added to impart antibacterial and osteogenic properties to the coatings, respectively. In order to examine the surface morphology of coatings, optical microscopy and scanning electron microscopy (SEM) were performed. To analyze mechanical strength, a pencil scratch test, bend test, and corrosion and wear tests were conducted on zein/Ag-Sr doped MBGN coatings. The results show good adhesion strength, wettability, corrosion, and wear resistance for zein/Ag-Sr doped MBGN coatings as compared to bare SS substrate. Thus, good mechanical and biological properties were observed for zein/Ag-Sr doped MBGN coatings. Results suggested these zein/Ag-Sr MBGNs coatings have great potential in bone regeneration applications. MDPI 2022-08-04 /pmc/articles/PMC9404864/ /pubmed/36004892 http://dx.doi.org/10.3390/bioengineering9080367 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Batool, Syeda Ammara
Liaquat, Ushna
Channa, Iftikhar Ahmad
Gilani, Sadaf Jamal
Makhdoom, Muhammad Atif
Yasir, Muhammad
Ashfaq, Jaweria
Jumah, May Nasser bin
Rehman, Muhammad Atiq ur
Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications
title Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications
title_full Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications
title_fullStr Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications
title_full_unstemmed Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications
title_short Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications
title_sort development and characterization of zein/ag-sr doped mesoporous bioactive glass nanoparticles coatings for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404864/
https://www.ncbi.nlm.nih.gov/pubmed/36004892
http://dx.doi.org/10.3390/bioengineering9080367
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