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Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients

It is widely known that blood stream infections (BSIs) in critically ill patients may affect mortality, length of stay, or the duration of mechanical ventilation. There is scarce data regarding blood stream infections in mechanically ventilated COVID-19 patients. Preliminary studies report that the...

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Autores principales: Mantzarlis, Konstantinos, Deskata, Konstantina, Papaspyrou, Dimitra, Leontopoulou, Vassiliki, Tsolaki, Vassiliki, Zakynthinos, Epaminondas, Makris, Demosthenes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404887/
https://www.ncbi.nlm.nih.gov/pubmed/36009922
http://dx.doi.org/10.3390/antibiotics11081053
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author Mantzarlis, Konstantinos
Deskata, Konstantina
Papaspyrou, Dimitra
Leontopoulou, Vassiliki
Tsolaki, Vassiliki
Zakynthinos, Epaminondas
Makris, Demosthenes
author_facet Mantzarlis, Konstantinos
Deskata, Konstantina
Papaspyrou, Dimitra
Leontopoulou, Vassiliki
Tsolaki, Vassiliki
Zakynthinos, Epaminondas
Makris, Demosthenes
author_sort Mantzarlis, Konstantinos
collection PubMed
description It is widely known that blood stream infections (BSIs) in critically ill patients may affect mortality, length of stay, or the duration of mechanical ventilation. There is scarce data regarding blood stream infections in mechanically ventilated COVID-19 patients. Preliminary studies report that the number of secondary infections in COVID-9 patients may be higher. This retrospective analysis was conducted to determine the incidence of BSI. Furthermore, risk factors, mortality, and other outcomes were analyzed. The setting was an Intensive Care Unit (ICU) at a University Hospital. Patients suffering from SARS-CoV-2 infection and requiring mechanical ventilation (MV) for >48 h were eligible. The characteristics of patients who presented BSI were compared with those of patients who did not present BSI. Eighty-four patients were included. The incidence of BSI was 57%. In most cases, multidrug-resistant pathogens were isolated. Dyslipidemia was more frequent in the BSI group (p < 0.05). Moreover, BSI-group patients had a longer ICU stay and a longer duration of both mechanical ventilation and sedation (p < 0.05). Deaths were not statistically different between the two groups (73% for BSI and 56% for the non-BSI group, p > 0.05). Compared with non-survivors, survivors had lower baseline APACHE II and SOFA scores, lower D-dimers levels, a higher baseline compliance of the respiratory system, and less frequent heart failure. They received anakinra less frequently and appropriate therapy more often (p < 0.05). The independent risk factor for mortality was the APACHE II score [1.232 (1.017 to 1.493), p = 0.033].
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spelling pubmed-94048872022-08-26 Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients Mantzarlis, Konstantinos Deskata, Konstantina Papaspyrou, Dimitra Leontopoulou, Vassiliki Tsolaki, Vassiliki Zakynthinos, Epaminondas Makris, Demosthenes Antibiotics (Basel) Article It is widely known that blood stream infections (BSIs) in critically ill patients may affect mortality, length of stay, or the duration of mechanical ventilation. There is scarce data regarding blood stream infections in mechanically ventilated COVID-19 patients. Preliminary studies report that the number of secondary infections in COVID-9 patients may be higher. This retrospective analysis was conducted to determine the incidence of BSI. Furthermore, risk factors, mortality, and other outcomes were analyzed. The setting was an Intensive Care Unit (ICU) at a University Hospital. Patients suffering from SARS-CoV-2 infection and requiring mechanical ventilation (MV) for >48 h were eligible. The characteristics of patients who presented BSI were compared with those of patients who did not present BSI. Eighty-four patients were included. The incidence of BSI was 57%. In most cases, multidrug-resistant pathogens were isolated. Dyslipidemia was more frequent in the BSI group (p < 0.05). Moreover, BSI-group patients had a longer ICU stay and a longer duration of both mechanical ventilation and sedation (p < 0.05). Deaths were not statistically different between the two groups (73% for BSI and 56% for the non-BSI group, p > 0.05). Compared with non-survivors, survivors had lower baseline APACHE II and SOFA scores, lower D-dimers levels, a higher baseline compliance of the respiratory system, and less frequent heart failure. They received anakinra less frequently and appropriate therapy more often (p < 0.05). The independent risk factor for mortality was the APACHE II score [1.232 (1.017 to 1.493), p = 0.033]. MDPI 2022-08-03 /pmc/articles/PMC9404887/ /pubmed/36009922 http://dx.doi.org/10.3390/antibiotics11081053 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mantzarlis, Konstantinos
Deskata, Konstantina
Papaspyrou, Dimitra
Leontopoulou, Vassiliki
Tsolaki, Vassiliki
Zakynthinos, Epaminondas
Makris, Demosthenes
Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients
title Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients
title_full Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients
title_fullStr Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients
title_full_unstemmed Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients
title_short Incidence and Risk Factors for Blood Stream Infection in Mechanically Ventilated COVID-19 Patients
title_sort incidence and risk factors for blood stream infection in mechanically ventilated covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404887/
https://www.ncbi.nlm.nih.gov/pubmed/36009922
http://dx.doi.org/10.3390/antibiotics11081053
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