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Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma

Pheochromocytomas and paragangliomas are endocrine tumors belonging to the family of neural crest cell-derived neoplasms. They have an extremely variable clinical course, characterized by a non-negligible percentage of relapse and/or metastasis after radical surgery. To date, there are no reliable m...

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Autores principales: Bima, Chiara, Bioletto, Fabio, Lopez, Chiara, Bollati, Martina, Arata, Stefano, Procopio, Matteo, Gesmundo, Iacopo, Ghigo, Ezio, Maccario, Mauro, Parasiliti-Caprino, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404897/
https://www.ncbi.nlm.nih.gov/pubmed/36009360
http://dx.doi.org/10.3390/biomedicines10081813
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author Bima, Chiara
Bioletto, Fabio
Lopez, Chiara
Bollati, Martina
Arata, Stefano
Procopio, Matteo
Gesmundo, Iacopo
Ghigo, Ezio
Maccario, Mauro
Parasiliti-Caprino, Mirko
author_facet Bima, Chiara
Bioletto, Fabio
Lopez, Chiara
Bollati, Martina
Arata, Stefano
Procopio, Matteo
Gesmundo, Iacopo
Ghigo, Ezio
Maccario, Mauro
Parasiliti-Caprino, Mirko
author_sort Bima, Chiara
collection PubMed
description Pheochromocytomas and paragangliomas are endocrine tumors belonging to the family of neural crest cell-derived neoplasms. They have an extremely variable clinical course, characterized by a non-negligible percentage of relapse and/or metastasis after radical surgery. To date, there are no reliable methods to predict the metastatic potential of these neoplasms, despite several clinical, molecular, and histopathological factors that have been extensively studied in the literature as predictors of the recurrence and/or metastasis in these neoplasms with different performances and results. In this review, we aimed to discuss and analyze the most important clinical and histopathological tools for predicting recurrence risk in patients affected by pheochromocytomas or paragangliomas. Thus, we compared the main available predictive models, exploring their applications in stratifying patients’ risks. In conclusion, we underlined the importance of simple and validated tools to better define disease aggressiveness and establish tailored patients’ treatments and follow-ups.
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spelling pubmed-94048972022-08-26 Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma Bima, Chiara Bioletto, Fabio Lopez, Chiara Bollati, Martina Arata, Stefano Procopio, Matteo Gesmundo, Iacopo Ghigo, Ezio Maccario, Mauro Parasiliti-Caprino, Mirko Biomedicines Review Pheochromocytomas and paragangliomas are endocrine tumors belonging to the family of neural crest cell-derived neoplasms. They have an extremely variable clinical course, characterized by a non-negligible percentage of relapse and/or metastasis after radical surgery. To date, there are no reliable methods to predict the metastatic potential of these neoplasms, despite several clinical, molecular, and histopathological factors that have been extensively studied in the literature as predictors of the recurrence and/or metastasis in these neoplasms with different performances and results. In this review, we aimed to discuss and analyze the most important clinical and histopathological tools for predicting recurrence risk in patients affected by pheochromocytomas or paragangliomas. Thus, we compared the main available predictive models, exploring their applications in stratifying patients’ risks. In conclusion, we underlined the importance of simple and validated tools to better define disease aggressiveness and establish tailored patients’ treatments and follow-ups. MDPI 2022-07-28 /pmc/articles/PMC9404897/ /pubmed/36009360 http://dx.doi.org/10.3390/biomedicines10081813 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bima, Chiara
Bioletto, Fabio
Lopez, Chiara
Bollati, Martina
Arata, Stefano
Procopio, Matteo
Gesmundo, Iacopo
Ghigo, Ezio
Maccario, Mauro
Parasiliti-Caprino, Mirko
Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma
title Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma
title_full Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma
title_fullStr Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma
title_full_unstemmed Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma
title_short Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma
title_sort clinical and pathological tools for predicting recurrence and/or metastasis in patients with pheochromocytoma and paraganglioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404897/
https://www.ncbi.nlm.nih.gov/pubmed/36009360
http://dx.doi.org/10.3390/biomedicines10081813
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