Doxorubicin Induces Bone Loss by Increasing Autophagy through a Mitochondrial ROS/TRPML1/TFEB Axis in Osteoclasts

Doxorubicin (DOX), a widely used chemotherapeutic agent, has been linked to an increased risk of bone damage in human patients and induces bone loss in mice. DOX induces autophagy, which contributes to bone homeostasis and excess autophagy in osteoclasts (OCs), resulting in bone loss. We hypothesize...

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Detalles Bibliográficos
Autores principales: Park, Hyun-Jung, Yoon, Sun-Young, Park, Jung-Nam, Suh, Jae-Hee, Choi, Hye-Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404930/
https://www.ncbi.nlm.nih.gov/pubmed/36009195
http://dx.doi.org/10.3390/antiox11081476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404930/
https://www.ncbi.nlm.nih.gov/pubmed/36009195
http://dx.doi.org/10.3390/antiox11081476

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