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Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality

Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD). This has been attributed to abnormal HDL function in CK...

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Autores principales: Ritsch, Andreas, Hunjadi, Monika, Stojakovic, Tatjana, Scherberich, Jürgen E., Silbernagel, Günther, Scharnagl, Hubert, Delgado, Graciela E., Kleber, Marcus E., März, Winfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404976/
https://www.ncbi.nlm.nih.gov/pubmed/36009383
http://dx.doi.org/10.3390/biomedicines10081832
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author Ritsch, Andreas
Hunjadi, Monika
Stojakovic, Tatjana
Scherberich, Jürgen E.
Silbernagel, Günther
Scharnagl, Hubert
Delgado, Graciela E.
Kleber, Marcus E.
März, Winfried
author_facet Ritsch, Andreas
Hunjadi, Monika
Stojakovic, Tatjana
Scherberich, Jürgen E.
Silbernagel, Günther
Scharnagl, Hubert
Delgado, Graciela E.
Kleber, Marcus E.
März, Winfried
author_sort Ritsch, Andreas
collection PubMed
description Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD). This has been attributed to abnormal HDL function in CKD. Methods: In this study, we analyzed the association of genetic markers for kidney function with cholesterol efflux capacity as one of the major HDL functions, as well as with cardiovascular mortality, in 2469 patients of the Ludwigshafen Risk and Cardiovascular Health Study who all underwent coronary angiography. Results: A genetic score of 53 SNPs associated with GRF and the uromodulin SNP rs12917707 were inversely correlated with cholesterol efflux capacity. This was in line with the observed association between cholesterol efflux capacity and kidney function in these patients. Adjustment for eGFR and uromodulin as markers of kidney function did not affect the relationship between cholesterol efflux and cardiovascular mortality. Conclusions: Our data propose the view that cholesterol efflux and kidney function are exerting their effects on cardiovascular mortality via different and independent pathways. Decreased cholesterol efflux may therefore not mediate the effects of impaired kidney function on cardiovascular mortality.
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spelling pubmed-94049762022-08-26 Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality Ritsch, Andreas Hunjadi, Monika Stojakovic, Tatjana Scherberich, Jürgen E. Silbernagel, Günther Scharnagl, Hubert Delgado, Graciela E. Kleber, Marcus E. März, Winfried Biomedicines Article Background: Impaired renal function is associated with cardiovascular and all-cause mortality. In the general population, HDL-cholesterol is associated with cardiovascular events, which is not true in patients with chronic kidney disease (CKD). This has been attributed to abnormal HDL function in CKD. Methods: In this study, we analyzed the association of genetic markers for kidney function with cholesterol efflux capacity as one of the major HDL functions, as well as with cardiovascular mortality, in 2469 patients of the Ludwigshafen Risk and Cardiovascular Health Study who all underwent coronary angiography. Results: A genetic score of 53 SNPs associated with GRF and the uromodulin SNP rs12917707 were inversely correlated with cholesterol efflux capacity. This was in line with the observed association between cholesterol efflux capacity and kidney function in these patients. Adjustment for eGFR and uromodulin as markers of kidney function did not affect the relationship between cholesterol efflux and cardiovascular mortality. Conclusions: Our data propose the view that cholesterol efflux and kidney function are exerting their effects on cardiovascular mortality via different and independent pathways. Decreased cholesterol efflux may therefore not mediate the effects of impaired kidney function on cardiovascular mortality. MDPI 2022-07-29 /pmc/articles/PMC9404976/ /pubmed/36009383 http://dx.doi.org/10.3390/biomedicines10081832 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ritsch, Andreas
Hunjadi, Monika
Stojakovic, Tatjana
Scherberich, Jürgen E.
Silbernagel, Günther
Scharnagl, Hubert
Delgado, Graciela E.
Kleber, Marcus E.
März, Winfried
Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
title Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
title_full Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
title_fullStr Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
title_full_unstemmed Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
title_short Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
title_sort independent effects of kidney function and cholesterol efflux on cardiovascular mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9404976/
https://www.ncbi.nlm.nih.gov/pubmed/36009383
http://dx.doi.org/10.3390/biomedicines10081832
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