Cargando…
Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial
Individuals with familial hypercholesterolemia (FH) have an increased risk of cardiovascular disease. Treatment is mainly low-density lipoprotein cholesterol (LDL-C) reduction. How omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplements affect lipoproteins in FH subjects is unknown. We hypothesi...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405021/ https://www.ncbi.nlm.nih.gov/pubmed/36009356 http://dx.doi.org/10.3390/biomedicines10081809 |
_version_ | 1784773777441161216 |
---|---|
author | Hande, Liv Nesse Kjellmo, Christian Pettersen, Kristin Ljunggren, Stefan Karlsson, Helen Cederbrant, Karin Marcusson-Ståhl, Maritha Hovland, Anders Lappegård, Knut Tore |
author_facet | Hande, Liv Nesse Kjellmo, Christian Pettersen, Kristin Ljunggren, Stefan Karlsson, Helen Cederbrant, Karin Marcusson-Ståhl, Maritha Hovland, Anders Lappegård, Knut Tore |
author_sort | Hande, Liv Nesse |
collection | PubMed |
description | Individuals with familial hypercholesterolemia (FH) have an increased risk of cardiovascular disease. Treatment is mainly low-density lipoprotein cholesterol (LDL-C) reduction. How omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplements affect lipoproteins in FH subjects is unknown. We hypothesized that a high-dose n-3 PUFA supplement would reduce atherogenic lipoproteins and influence the high-density lipoprotein cholesterol (HDL-C) function. We performed a randomized, double-blinded crossover study with 34 genetically verified FH individuals (18–75 years, clinically stable, statin treatment > 12 months). Treatment was 4 g n-3 PUFAs (1840 mg eicosapentaenoic acid and 1520 mg docosahexaenoic acid daily) or four capsules of olive oil for three months in a crossover design with a washout period of three months. The defined outcomes were changes in triglycerides, lipoproteins, lipoprotein subfractions, apolipoproteins, and HDL-C function. After treatment with n-3 PUFAs, total cholesterol, LDL-C, and triglycerides were reduced compared to placebo (p ≤ 0.01 for all). Total HDL-C levels were unchanged, but the subfraction of large HDL-C was higher (p ≤ 0.0001) after n-3 PUFAs than after placebo, and intermediate HDL-C and small HDL-C were reduced after n-3 PUFAs compared to placebo (p = 0.02 and p ≤ 0.001, respectively). No changes were found in apolipoproteins and HDL-C function. N-3 PUFAs supplements reduced atherogenic lipoproteins in FH subjects, leaving HDL-C function unaffected. |
format | Online Article Text |
id | pubmed-9405021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94050212022-08-26 Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial Hande, Liv Nesse Kjellmo, Christian Pettersen, Kristin Ljunggren, Stefan Karlsson, Helen Cederbrant, Karin Marcusson-Ståhl, Maritha Hovland, Anders Lappegård, Knut Tore Biomedicines Article Individuals with familial hypercholesterolemia (FH) have an increased risk of cardiovascular disease. Treatment is mainly low-density lipoprotein cholesterol (LDL-C) reduction. How omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplements affect lipoproteins in FH subjects is unknown. We hypothesized that a high-dose n-3 PUFA supplement would reduce atherogenic lipoproteins and influence the high-density lipoprotein cholesterol (HDL-C) function. We performed a randomized, double-blinded crossover study with 34 genetically verified FH individuals (18–75 years, clinically stable, statin treatment > 12 months). Treatment was 4 g n-3 PUFAs (1840 mg eicosapentaenoic acid and 1520 mg docosahexaenoic acid daily) or four capsules of olive oil for three months in a crossover design with a washout period of three months. The defined outcomes were changes in triglycerides, lipoproteins, lipoprotein subfractions, apolipoproteins, and HDL-C function. After treatment with n-3 PUFAs, total cholesterol, LDL-C, and triglycerides were reduced compared to placebo (p ≤ 0.01 for all). Total HDL-C levels were unchanged, but the subfraction of large HDL-C was higher (p ≤ 0.0001) after n-3 PUFAs than after placebo, and intermediate HDL-C and small HDL-C were reduced after n-3 PUFAs compared to placebo (p = 0.02 and p ≤ 0.001, respectively). No changes were found in apolipoproteins and HDL-C function. N-3 PUFAs supplements reduced atherogenic lipoproteins in FH subjects, leaving HDL-C function unaffected. MDPI 2022-07-27 /pmc/articles/PMC9405021/ /pubmed/36009356 http://dx.doi.org/10.3390/biomedicines10081809 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hande, Liv Nesse Kjellmo, Christian Pettersen, Kristin Ljunggren, Stefan Karlsson, Helen Cederbrant, Karin Marcusson-Ståhl, Maritha Hovland, Anders Lappegård, Knut Tore Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial |
title | Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial |
title_full | Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial |
title_fullStr | Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial |
title_full_unstemmed | Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial |
title_short | Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial |
title_sort | effect of n-3 polyunsaturated fatty acids on lipid composition in familial hypercholesterolemia: a randomized crossover trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405021/ https://www.ncbi.nlm.nih.gov/pubmed/36009356 http://dx.doi.org/10.3390/biomedicines10081809 |
work_keys_str_mv | AT handelivnesse effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT kjellmochristian effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT pettersenkristin effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT ljunggrenstefan effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT karlssonhelen effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT cederbrantkarin effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT marcussonstahlmaritha effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT hovlandanders effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial AT lappegardknuttore effectofn3polyunsaturatedfattyacidsonlipidcompositioninfamilialhypercholesterolemiaarandomizedcrossovertrial |