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Pharmacodynamics of Flucloxacillin in a Neutropenic Murine Thigh Infection Model: A Piece of the Puzzle towards Evidence-Based Dosing

For decades, flucloxacillin has been used to treat methicillin-susceptible Staphylococcus aureus (MSSA). Little is still known about its pharmacodynamics (PD). The present study aimed to determine the pharmacokinetic (PK)/PD index and the PD-index value minimally required for efficacy. MICs of 305 M...

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Detalles Bibliográficos
Autores principales:	Roelofsen, Eveline E., de Winter, Brenda C. M., van der Spek, Heleen, Snijders, Susan, Koch, Birgit C. P., van den Berg, Sanne, Muller, Anouk E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405042/ https://www.ncbi.nlm.nih.gov/pubmed/36009918 http://dx.doi.org/10.3390/antibiotics11081049

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