Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication

Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) are two similar bone pathologies in the jaw with different aetiologies. Actinomycosis is a relatively rare oral infection caused by the Gram-positive anaerobe Actinomyces sp. that normally colonizes the oral cavity. Act...

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Autores principales: Ibrahim, Norliwati, Apandi, Nurul Inaas Mahamad, Shuhardi, Syafiqah Aina, Ramli, Roszalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405108/
https://www.ncbi.nlm.nih.gov/pubmed/36009936
http://dx.doi.org/10.3390/antibiotics11081067
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author Ibrahim, Norliwati
Apandi, Nurul Inaas Mahamad
Shuhardi, Syafiqah Aina
Ramli, Roszalina
author_facet Ibrahim, Norliwati
Apandi, Nurul Inaas Mahamad
Shuhardi, Syafiqah Aina
Ramli, Roszalina
author_sort Ibrahim, Norliwati
collection PubMed
description Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) are two similar bone pathologies in the jaw with different aetiologies. Actinomycosis is a relatively rare oral infection caused by the Gram-positive anaerobe Actinomyces sp. that normally colonizes the oral cavity. Actinomycosis is associated with the pathogenesis of both the MRONJ and ORN, as evident in our cases, and not just as a superficial contaminant. The clinical and histopathological aspects of the cases treated in our centre were also reported with a review of the literature. Clinical implication on the treatment of the cases was highlighted in view of the presence of this microorganism.
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spelling pubmed-94051082022-08-26 Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication Ibrahim, Norliwati Apandi, Nurul Inaas Mahamad Shuhardi, Syafiqah Aina Ramli, Roszalina Antibiotics (Basel) Case Report Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) are two similar bone pathologies in the jaw with different aetiologies. Actinomycosis is a relatively rare oral infection caused by the Gram-positive anaerobe Actinomyces sp. that normally colonizes the oral cavity. Actinomycosis is associated with the pathogenesis of both the MRONJ and ORN, as evident in our cases, and not just as a superficial contaminant. The clinical and histopathological aspects of the cases treated in our centre were also reported with a review of the literature. Clinical implication on the treatment of the cases was highlighted in view of the presence of this microorganism. MDPI 2022-08-05 /pmc/articles/PMC9405108/ /pubmed/36009936 http://dx.doi.org/10.3390/antibiotics11081067 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ibrahim, Norliwati
Apandi, Nurul Inaas Mahamad
Shuhardi, Syafiqah Aina
Ramli, Roszalina
Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication
title Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication
title_full Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication
title_fullStr Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication
title_full_unstemmed Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication
title_short Actinomyces sp. Presence in the Bone Specimens of Patients with Osteonecrosis of the Jaw: The Histopathological Analysis and Clinical Implication
title_sort actinomyces sp. presence in the bone specimens of patients with osteonecrosis of the jaw: the histopathological analysis and clinical implication
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405108/
https://www.ncbi.nlm.nih.gov/pubmed/36009936
http://dx.doi.org/10.3390/antibiotics11081067
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