Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors

Methionine aminopeptidases (MetAPs) are attractive drug targets due to their essential role in eukaryotes as well as prokaryotic cells. In this study, biochemical assays were performed on newly synthesized Isatin-pyrazole hydrazones (PS1–14) to identify potent and selective bacterial MetAPs inhibito...

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Detalles Bibliográficos
Autores principales: Irfan, Iram, Ali, Asghar, Reddi, Bharati, Khan, Mohd. Abrar, Hasan, Phool, Ahmed, Sarfraz, Uddin, Amad, Piatek, Magdalena, Kavanagh, Kevin, Haque, Qazi Mohd. Rizwanul, Singh, Shailja, Addlagatta, Anthony, Abid, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405123/
https://www.ncbi.nlm.nih.gov/pubmed/36009995
http://dx.doi.org/10.3390/antibiotics11081126

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