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Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis
In our continued search for biologically active metabolites from cultures of rare Basidiomycota species, we found eight previously undescribed cyathane-xylosides from submerged cultures of Dentipellis fragilis, which were named dentifragilins A–H. In addition, the known cyathane derivatives striatal...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405216/ https://www.ncbi.nlm.nih.gov/pubmed/36009941 http://dx.doi.org/10.3390/antibiotics11081072 |
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author | Sum, Winnie Chemutai Mitschke, Nico Schrey, Hedda Wittstein, Kathrin Kellner, Harald Stadler, Marc Matasyoh, Josphat Clement |
author_facet | Sum, Winnie Chemutai Mitschke, Nico Schrey, Hedda Wittstein, Kathrin Kellner, Harald Stadler, Marc Matasyoh, Josphat Clement |
author_sort | Sum, Winnie Chemutai |
collection | PubMed |
description | In our continued search for biologically active metabolites from cultures of rare Basidiomycota species, we found eight previously undescribed cyathane-xylosides from submerged cultures of Dentipellis fragilis, which were named dentifragilins A–H. In addition, the known cyathane derivatives striatal D and laxitextine A were isolated. All compounds were characterized by high-resolution electrospray ionization mass spectrometry (HR-ESIMS) as well as by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. Several of the compounds exhibited significant activities in standardized cell-based assays for the determination of antimicrobial and cytotoxic effects. The discovery of cyathanes in the genus Dentipellis has chemotaxonomic implications, as this class of diterpenoids has already been shown to be characteristic for mycelial cultures of the related genera Hericium and Laxitextum, which are classified as Dentipellis in the family Hericiaceae. |
format | Online Article Text |
id | pubmed-9405216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94052162022-08-26 Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis Sum, Winnie Chemutai Mitschke, Nico Schrey, Hedda Wittstein, Kathrin Kellner, Harald Stadler, Marc Matasyoh, Josphat Clement Antibiotics (Basel) Article In our continued search for biologically active metabolites from cultures of rare Basidiomycota species, we found eight previously undescribed cyathane-xylosides from submerged cultures of Dentipellis fragilis, which were named dentifragilins A–H. In addition, the known cyathane derivatives striatal D and laxitextine A were isolated. All compounds were characterized by high-resolution electrospray ionization mass spectrometry (HR-ESIMS) as well as by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. Several of the compounds exhibited significant activities in standardized cell-based assays for the determination of antimicrobial and cytotoxic effects. The discovery of cyathanes in the genus Dentipellis has chemotaxonomic implications, as this class of diterpenoids has already been shown to be characteristic for mycelial cultures of the related genera Hericium and Laxitextum, which are classified as Dentipellis in the family Hericiaceae. MDPI 2022-08-08 /pmc/articles/PMC9405216/ /pubmed/36009941 http://dx.doi.org/10.3390/antibiotics11081072 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sum, Winnie Chemutai Mitschke, Nico Schrey, Hedda Wittstein, Kathrin Kellner, Harald Stadler, Marc Matasyoh, Josphat Clement Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis |
title | Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis |
title_full | Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis |
title_fullStr | Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis |
title_full_unstemmed | Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis |
title_short | Antimicrobial and Cytotoxic Cyathane-Xylosides from Cultures of the Basidiomycete Dentipellis fragilis |
title_sort | antimicrobial and cytotoxic cyathane-xylosides from cultures of the basidiomycete dentipellis fragilis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405216/ https://www.ncbi.nlm.nih.gov/pubmed/36009941 http://dx.doi.org/10.3390/antibiotics11081072 |
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