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Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review

Imbalances of the oral microbiota and dysbiosis have traditionally been linked to the occurrence of teeth and oral diseases. However, recent findings indicate that this microbiota exerts relevant influence in systemic health. Dysbiosis of the oral microbiota is implicated in the apparition and progr...

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Autores principales: Giordano-Kelhoffer, Barbara, Lorca, Cristina, March Llanes, Jaume, Rábano, Alberto, del Ser, Teodoro, Serra, Aida, Gallart-Palau, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405223/
https://www.ncbi.nlm.nih.gov/pubmed/36009350
http://dx.doi.org/10.3390/biomedicines10081803
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author Giordano-Kelhoffer, Barbara
Lorca, Cristina
March Llanes, Jaume
Rábano, Alberto
del Ser, Teodoro
Serra, Aida
Gallart-Palau, Xavier
author_facet Giordano-Kelhoffer, Barbara
Lorca, Cristina
March Llanes, Jaume
Rábano, Alberto
del Ser, Teodoro
Serra, Aida
Gallart-Palau, Xavier
author_sort Giordano-Kelhoffer, Barbara
collection PubMed
description Imbalances of the oral microbiota and dysbiosis have traditionally been linked to the occurrence of teeth and oral diseases. However, recent findings indicate that this microbiota exerts relevant influence in systemic health. Dysbiosis of the oral microbiota is implicated in the apparition and progression of cardiovascular, neurodegenerative and other major human diseases. In fact, the oral microbiota are the second most diverse and largely populated microbiota of the human body and its relationships with systemic health, although widely explored, they still lack of proper integration. The purpose of this systematic review is thus to widely examine the implications of oral microbiota in oral, cardiovascular and neurodegenerative diseases to offer integrative and up-to-date interpretations. To achieve that aim, we identified a total of 121 studies curated in PUBMED from the time interval January 2003–April 2022, which after careful screening resulted in 79 studies included. The reviewed scientific literature provides plausible vias of implication of dysbiotic oral microbiota in systemic human diseases, and encourages further research to continue elucidating the highly relevant and still poorly understood implications of this niche microbiota in systemic health. PROSPERO Registration Number: CRD42022299692. This systematic review follows relevant PRISMA guidelines.
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spelling pubmed-94052232022-08-26 Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review Giordano-Kelhoffer, Barbara Lorca, Cristina March Llanes, Jaume Rábano, Alberto del Ser, Teodoro Serra, Aida Gallart-Palau, Xavier Biomedicines Systematic Review Imbalances of the oral microbiota and dysbiosis have traditionally been linked to the occurrence of teeth and oral diseases. However, recent findings indicate that this microbiota exerts relevant influence in systemic health. Dysbiosis of the oral microbiota is implicated in the apparition and progression of cardiovascular, neurodegenerative and other major human diseases. In fact, the oral microbiota are the second most diverse and largely populated microbiota of the human body and its relationships with systemic health, although widely explored, they still lack of proper integration. The purpose of this systematic review is thus to widely examine the implications of oral microbiota in oral, cardiovascular and neurodegenerative diseases to offer integrative and up-to-date interpretations. To achieve that aim, we identified a total of 121 studies curated in PUBMED from the time interval January 2003–April 2022, which after careful screening resulted in 79 studies included. The reviewed scientific literature provides plausible vias of implication of dysbiotic oral microbiota in systemic human diseases, and encourages further research to continue elucidating the highly relevant and still poorly understood implications of this niche microbiota in systemic health. PROSPERO Registration Number: CRD42022299692. This systematic review follows relevant PRISMA guidelines. MDPI 2022-07-27 /pmc/articles/PMC9405223/ /pubmed/36009350 http://dx.doi.org/10.3390/biomedicines10081803 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Giordano-Kelhoffer, Barbara
Lorca, Cristina
March Llanes, Jaume
Rábano, Alberto
del Ser, Teodoro
Serra, Aida
Gallart-Palau, Xavier
Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review
title Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review
title_full Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review
title_fullStr Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review
title_full_unstemmed Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review
title_short Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review
title_sort oral microbiota, its equilibrium and implications in the pathophysiology of human diseases: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405223/
https://www.ncbi.nlm.nih.gov/pubmed/36009350
http://dx.doi.org/10.3390/biomedicines10081803
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