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Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus

Inonotus hispidus mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites derived from I. hispidus...

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Autores principales: Wang, Zhen-xin, Feng, Xi-long, Liu, Chengwei, Gao, Jin-ming, Qi, Jianzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405263/
https://www.ncbi.nlm.nih.gov/pubmed/36009965
http://dx.doi.org/10.3390/antibiotics11081097
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author Wang, Zhen-xin
Feng, Xi-long
Liu, Chengwei
Gao, Jin-ming
Qi, Jianzhao
author_facet Wang, Zhen-xin
Feng, Xi-long
Liu, Chengwei
Gao, Jin-ming
Qi, Jianzhao
author_sort Wang, Zhen-xin
collection PubMed
description Inonotus hispidus mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites derived from I. hispidus and their biological activities have been discovered and investigated. Structurally, these compounds are mainly polyphenols and triterpenoids, which have anticancer, anti-inflammatory, antioxidant, antimicrobial, and enzyme inhibitor activities. Here, the secondary metabolites derived from I. hispidus and their activities were systematically and comprehensively classified and summarized, and the biosynthetic pathway of stylylpyrones was deduced and analyzed further. This review contributes to our understanding of I. hispidus and will help with research into natural product chemistry, pharmacology, and the biosynthesis of I. hispidus metabolites. According to this review, I. hispidus could be a promising source of bioactive compounds for health promotion and the development of functional foods.
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spelling pubmed-94052632022-08-26 Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus Wang, Zhen-xin Feng, Xi-long Liu, Chengwei Gao, Jin-ming Qi, Jianzhao Antibiotics (Basel) Review Inonotus hispidus mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites derived from I. hispidus and their biological activities have been discovered and investigated. Structurally, these compounds are mainly polyphenols and triterpenoids, which have anticancer, anti-inflammatory, antioxidant, antimicrobial, and enzyme inhibitor activities. Here, the secondary metabolites derived from I. hispidus and their activities were systematically and comprehensively classified and summarized, and the biosynthetic pathway of stylylpyrones was deduced and analyzed further. This review contributes to our understanding of I. hispidus and will help with research into natural product chemistry, pharmacology, and the biosynthesis of I. hispidus metabolites. According to this review, I. hispidus could be a promising source of bioactive compounds for health promotion and the development of functional foods. MDPI 2022-08-12 /pmc/articles/PMC9405263/ /pubmed/36009965 http://dx.doi.org/10.3390/antibiotics11081097 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Zhen-xin
Feng, Xi-long
Liu, Chengwei
Gao, Jin-ming
Qi, Jianzhao
Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus
title Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus
title_full Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus
title_fullStr Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus
title_full_unstemmed Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus
title_short Diverse Metabolites and Pharmacological Effects from the Basidiomycetes Inonotus hispidus
title_sort diverse metabolites and pharmacological effects from the basidiomycetes inonotus hispidus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405263/
https://www.ncbi.nlm.nih.gov/pubmed/36009965
http://dx.doi.org/10.3390/antibiotics11081097
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