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Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials
The increasingly widespread antimicrobial resistance forces the search for new antimicrobial substances capable of fighting infection. Antimicrobial peptides (AMPs) and their synthetic analogs form an extensive group of compounds of great structural diversity and multifunctionality, different modes...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405281/ https://www.ncbi.nlm.nih.gov/pubmed/36009931 http://dx.doi.org/10.3390/antibiotics11081062 |
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author | Lesiuk, Małgorzata Paduszyńska, Małgorzata Greber, Katarzyna E. |
author_facet | Lesiuk, Małgorzata Paduszyńska, Małgorzata Greber, Katarzyna E. |
author_sort | Lesiuk, Małgorzata |
collection | PubMed |
description | The increasingly widespread antimicrobial resistance forces the search for new antimicrobial substances capable of fighting infection. Antimicrobial peptides (AMPs) and their synthetic analogs form an extensive group of compounds of great structural diversity and multifunctionality, different modes of antimicrobial action, and considerable market potential. Some AMPs, in addition to their proven antibacterial, antifungal, and antiviral activity, also demonstrate anti-inflammatory and immunomodulatory capabilities; these are called innate defense regulator (IDR) peptides. IDR peptides stimulate or inhibit the body’s immune system, e.g., by stimulating leukocyte migration to the site of infection, driving macrophage differentiation and activation, providing chemotactic action for neutrophils, degranulation and activation of mast cells, altering chemokine and cytokine production, and even induction of angiogenesis and wound healing. Such multifunctional immunomodulatory peptide molecules are currently being investigated and developed. Exploring and utilizing IDR peptides as an indirect weapon against infectious diseases could represent a completely new strategy to cope with the issue of antimicrobial resistance. |
format | Online Article Text |
id | pubmed-9405281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94052812022-08-26 Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials Lesiuk, Małgorzata Paduszyńska, Małgorzata Greber, Katarzyna E. Antibiotics (Basel) Perspective The increasingly widespread antimicrobial resistance forces the search for new antimicrobial substances capable of fighting infection. Antimicrobial peptides (AMPs) and their synthetic analogs form an extensive group of compounds of great structural diversity and multifunctionality, different modes of antimicrobial action, and considerable market potential. Some AMPs, in addition to their proven antibacterial, antifungal, and antiviral activity, also demonstrate anti-inflammatory and immunomodulatory capabilities; these are called innate defense regulator (IDR) peptides. IDR peptides stimulate or inhibit the body’s immune system, e.g., by stimulating leukocyte migration to the site of infection, driving macrophage differentiation and activation, providing chemotactic action for neutrophils, degranulation and activation of mast cells, altering chemokine and cytokine production, and even induction of angiogenesis and wound healing. Such multifunctional immunomodulatory peptide molecules are currently being investigated and developed. Exploring and utilizing IDR peptides as an indirect weapon against infectious diseases could represent a completely new strategy to cope with the issue of antimicrobial resistance. MDPI 2022-08-05 /pmc/articles/PMC9405281/ /pubmed/36009931 http://dx.doi.org/10.3390/antibiotics11081062 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Lesiuk, Małgorzata Paduszyńska, Małgorzata Greber, Katarzyna E. Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
title | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
title_full | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
title_fullStr | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
title_full_unstemmed | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
title_short | Synthetic Antimicrobial Immunomodulatory Peptides: Ongoing Studies and Clinical Trials |
title_sort | synthetic antimicrobial immunomodulatory peptides: ongoing studies and clinical trials |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405281/ https://www.ncbi.nlm.nih.gov/pubmed/36009931 http://dx.doi.org/10.3390/antibiotics11081062 |
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