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Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants
Ozone pollution, is a serious health problem worldwide. Repeated exposure to low ozone doses causes a loss of regulation of the oxidation–reduction systems, and also induces a chronic state of oxidative stress. This fact is of special importance for the regulation of different systems including the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405302/ https://www.ncbi.nlm.nih.gov/pubmed/36009272 http://dx.doi.org/10.3390/antiox11081553 |
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author | Rivas-Arancibia, Selva Hernández-Orozco, Eduardo Rodríguez-Martínez, Erika Valdés-Fuentes, Marlen Cornejo-Trejo, Vanessa Pérez-Pacheco, Nelva Dorado-Martínez, Claudia Zequeida-Carmona, Diana Espinosa-Caleti, Isaac |
author_facet | Rivas-Arancibia, Selva Hernández-Orozco, Eduardo Rodríguez-Martínez, Erika Valdés-Fuentes, Marlen Cornejo-Trejo, Vanessa Pérez-Pacheco, Nelva Dorado-Martínez, Claudia Zequeida-Carmona, Diana Espinosa-Caleti, Isaac |
author_sort | Rivas-Arancibia, Selva |
collection | PubMed |
description | Ozone pollution, is a serious health problem worldwide. Repeated exposure to low ozone doses causes a loss of regulation of the oxidation–reduction systems, and also induces a chronic state of oxidative stress. This fact is of special importance for the regulation of different systems including the immune system and the inflammatory response. In addition, the oxidation–reduction balance modulates the homeostasis of these and other complex systems such as metabolism, survival capacity, cell renewal, and brain repair, etc. Likewise, it has been widely demonstrated that in chronic degenerative diseases, an alteration in the oxide-reduction balance is present, and this alteration causes a chronic loss in the regulation of the immune response and the inflammatory process. This is because reactive oxygen species disrupt different signaling pathways. Such pathways are related to the role of regulatory T cells (Treg) in inflammation. This causes an increase in chronic deterioration in the degenerative disease over time. The objective of this review was to study the relationship between environmental ozone pollution, the chronic state of oxidative stress and its effect on Treg cells, which causes the loss of regulation in the inflammatory response as well as the role played by antioxidant systems in various pathologies. |
format | Online Article Text |
id | pubmed-9405302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94053022022-08-26 Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants Rivas-Arancibia, Selva Hernández-Orozco, Eduardo Rodríguez-Martínez, Erika Valdés-Fuentes, Marlen Cornejo-Trejo, Vanessa Pérez-Pacheco, Nelva Dorado-Martínez, Claudia Zequeida-Carmona, Diana Espinosa-Caleti, Isaac Antioxidants (Basel) Review Ozone pollution, is a serious health problem worldwide. Repeated exposure to low ozone doses causes a loss of regulation of the oxidation–reduction systems, and also induces a chronic state of oxidative stress. This fact is of special importance for the regulation of different systems including the immune system and the inflammatory response. In addition, the oxidation–reduction balance modulates the homeostasis of these and other complex systems such as metabolism, survival capacity, cell renewal, and brain repair, etc. Likewise, it has been widely demonstrated that in chronic degenerative diseases, an alteration in the oxide-reduction balance is present, and this alteration causes a chronic loss in the regulation of the immune response and the inflammatory process. This is because reactive oxygen species disrupt different signaling pathways. Such pathways are related to the role of regulatory T cells (Treg) in inflammation. This causes an increase in chronic deterioration in the degenerative disease over time. The objective of this review was to study the relationship between environmental ozone pollution, the chronic state of oxidative stress and its effect on Treg cells, which causes the loss of regulation in the inflammatory response as well as the role played by antioxidant systems in various pathologies. MDPI 2022-08-11 /pmc/articles/PMC9405302/ /pubmed/36009272 http://dx.doi.org/10.3390/antiox11081553 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rivas-Arancibia, Selva Hernández-Orozco, Eduardo Rodríguez-Martínez, Erika Valdés-Fuentes, Marlen Cornejo-Trejo, Vanessa Pérez-Pacheco, Nelva Dorado-Martínez, Claudia Zequeida-Carmona, Diana Espinosa-Caleti, Isaac Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants |
title | Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants |
title_full | Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants |
title_fullStr | Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants |
title_full_unstemmed | Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants |
title_short | Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants |
title_sort | ozone pollution, oxidative stress, regulatory t cells and antioxidants |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405302/ https://www.ncbi.nlm.nih.gov/pubmed/36009272 http://dx.doi.org/10.3390/antiox11081553 |
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