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A Systematic Review on the Role of Vitamin C in Tissue Healing

Vitamin C is an essential nutrient for humans and animals which are unable to synthesise it themselves. Vitamin C is important for tissue regeneration due to the role it plays in collagen formation, and its antioxidant properties. We reviewed the literature to evaluate potential associations between...

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Autores principales: Bechara, Nada, Flood, Victoria M., Gunton, Jenny E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405326/
https://www.ncbi.nlm.nih.gov/pubmed/36009324
http://dx.doi.org/10.3390/antiox11081605
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author Bechara, Nada
Flood, Victoria M.
Gunton, Jenny E.
author_facet Bechara, Nada
Flood, Victoria M.
Gunton, Jenny E.
author_sort Bechara, Nada
collection PubMed
description Vitamin C is an essential nutrient for humans and animals which are unable to synthesise it themselves. Vitamin C is important for tissue regeneration due to the role it plays in collagen formation, and its antioxidant properties. We reviewed the literature to evaluate potential associations between vitamin C supplementation and healing of an acute or chronic condition. Embase, Medline, PubMed, and the Cochrane Library were searched for studies published prior to April 2022. Studies were eligible if they reported at least one association between vitamin C supplementation and healing outcomes. Eighteen studies met the inclusion criteria and were included in this review. Overall, vitamin C supplementation improved healing outcomes in certain pathologies, predominantly pressure ulcers. However, many of the studies had small sample sizes, combined nutritional treatments, and did not test baseline vitamin C. Future studies should be of larger scale, exclusively using vitamin C to determine its role in tissue healing in other wounds. We recommend consideration of vitamin C supplementation for people with pressure ulcers.
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spelling pubmed-94053262022-08-26 A Systematic Review on the Role of Vitamin C in Tissue Healing Bechara, Nada Flood, Victoria M. Gunton, Jenny E. Antioxidants (Basel) Systematic Review Vitamin C is an essential nutrient for humans and animals which are unable to synthesise it themselves. Vitamin C is important for tissue regeneration due to the role it plays in collagen formation, and its antioxidant properties. We reviewed the literature to evaluate potential associations between vitamin C supplementation and healing of an acute or chronic condition. Embase, Medline, PubMed, and the Cochrane Library were searched for studies published prior to April 2022. Studies were eligible if they reported at least one association between vitamin C supplementation and healing outcomes. Eighteen studies met the inclusion criteria and were included in this review. Overall, vitamin C supplementation improved healing outcomes in certain pathologies, predominantly pressure ulcers. However, many of the studies had small sample sizes, combined nutritional treatments, and did not test baseline vitamin C. Future studies should be of larger scale, exclusively using vitamin C to determine its role in tissue healing in other wounds. We recommend consideration of vitamin C supplementation for people with pressure ulcers. MDPI 2022-08-19 /pmc/articles/PMC9405326/ /pubmed/36009324 http://dx.doi.org/10.3390/antiox11081605 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Bechara, Nada
Flood, Victoria M.
Gunton, Jenny E.
A Systematic Review on the Role of Vitamin C in Tissue Healing
title A Systematic Review on the Role of Vitamin C in Tissue Healing
title_full A Systematic Review on the Role of Vitamin C in Tissue Healing
title_fullStr A Systematic Review on the Role of Vitamin C in Tissue Healing
title_full_unstemmed A Systematic Review on the Role of Vitamin C in Tissue Healing
title_short A Systematic Review on the Role of Vitamin C in Tissue Healing
title_sort systematic review on the role of vitamin c in tissue healing
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405326/
https://www.ncbi.nlm.nih.gov/pubmed/36009324
http://dx.doi.org/10.3390/antiox11081605
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