Cargando…

Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil

Diabetic foot infections (DFIs) are one of the causes of hospitalization in diabetic patients and, when this occurs, empirical antibiotic therapy is necessary. We have conducted a retrospective study of patients with DFI that required hospitalization to evaluate microbiologic profile and the suscept...

Descripción completa

Detalles Bibliográficos
Autores principales: Palomo, Amanda Thurler, Pires, Ana Paula Maia, Matielo, Marcelo Fernando, de Athayde Soares, Rafael, Pecego, Christiano, Sacilotto, Roberto, de Paula, Alexandre Inacio, Hosino, Nair, de Melo Gamba, Cristiano, Fonseca, Cibele Lefreve, Paraskevopoulos, Daniela K. S., Yamaguti, Augusto, de Mendonça, João Silva, Costa, Silvia Figueiredo, Guimarães, Thaís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405336/
https://www.ncbi.nlm.nih.gov/pubmed/36009994
http://dx.doi.org/10.3390/antibiotics11081125
_version_ 1784773855973212160
author Palomo, Amanda Thurler
Pires, Ana Paula Maia
Matielo, Marcelo Fernando
de Athayde Soares, Rafael
Pecego, Christiano
Sacilotto, Roberto
de Paula, Alexandre Inacio
Hosino, Nair
de Melo Gamba, Cristiano
Fonseca, Cibele Lefreve
Paraskevopoulos, Daniela K. S.
Yamaguti, Augusto
de Mendonça, João Silva
Costa, Silvia Figueiredo
Guimarães, Thaís
author_facet Palomo, Amanda Thurler
Pires, Ana Paula Maia
Matielo, Marcelo Fernando
de Athayde Soares, Rafael
Pecego, Christiano
Sacilotto, Roberto
de Paula, Alexandre Inacio
Hosino, Nair
de Melo Gamba, Cristiano
Fonseca, Cibele Lefreve
Paraskevopoulos, Daniela K. S.
Yamaguti, Augusto
de Mendonça, João Silva
Costa, Silvia Figueiredo
Guimarães, Thaís
author_sort Palomo, Amanda Thurler
collection PubMed
description Diabetic foot infections (DFIs) are one of the causes of hospitalization in diabetic patients and, when this occurs, empirical antibiotic therapy is necessary. We have conducted a retrospective study of patients with DFI that required hospitalization to evaluate microbiologic profile and the susceptibility pattern of these infections. We evaluated 320 patients, of which 223 (69.7%) were male with a media age of 71 years with 276 isolates. Gram-positive bacteria were responsible for 188 (68.1%) of the isolates, while Gram-negative bacilli were responsible for 88 (31.9%). E. faecalis was the most prevalent pathogen, followed by S. aureus and coagulase negative Staphylococci. Among Gram-negative pathogens, P. aeruginosa was the most prevalent agent. Regarding the susceptibility profile, we found ampicillin-sensitive enterococci in 89% of the cases, oxacillin-sensitive S. aureus in 47%, but in coagulase-negative staphylococci, oxacillin was sensible only in 20%. The susceptibility profile of Gram-negatives was very good with 76% susceptibility of P. aeruginosa to ceftazidime and meropenem. The other prevalent Enterobacterales had great susceptibility to ceftazidime, piperacillin-tazobactam and 100% susceptibility to meropenem, with the exception of K. pneumoniae, which had 75% susceptibility to meropenem. Knowledge of microbiological profile and susceptibility patterns of patients with DFIs is useful to guide empirical therapy.
format Online
Article
Text
id pubmed-9405336
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94053362022-08-26 Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil Palomo, Amanda Thurler Pires, Ana Paula Maia Matielo, Marcelo Fernando de Athayde Soares, Rafael Pecego, Christiano Sacilotto, Roberto de Paula, Alexandre Inacio Hosino, Nair de Melo Gamba, Cristiano Fonseca, Cibele Lefreve Paraskevopoulos, Daniela K. S. Yamaguti, Augusto de Mendonça, João Silva Costa, Silvia Figueiredo Guimarães, Thaís Antibiotics (Basel) Article Diabetic foot infections (DFIs) are one of the causes of hospitalization in diabetic patients and, when this occurs, empirical antibiotic therapy is necessary. We have conducted a retrospective study of patients with DFI that required hospitalization to evaluate microbiologic profile and the susceptibility pattern of these infections. We evaluated 320 patients, of which 223 (69.7%) were male with a media age of 71 years with 276 isolates. Gram-positive bacteria were responsible for 188 (68.1%) of the isolates, while Gram-negative bacilli were responsible for 88 (31.9%). E. faecalis was the most prevalent pathogen, followed by S. aureus and coagulase negative Staphylococci. Among Gram-negative pathogens, P. aeruginosa was the most prevalent agent. Regarding the susceptibility profile, we found ampicillin-sensitive enterococci in 89% of the cases, oxacillin-sensitive S. aureus in 47%, but in coagulase-negative staphylococci, oxacillin was sensible only in 20%. The susceptibility profile of Gram-negatives was very good with 76% susceptibility of P. aeruginosa to ceftazidime and meropenem. The other prevalent Enterobacterales had great susceptibility to ceftazidime, piperacillin-tazobactam and 100% susceptibility to meropenem, with the exception of K. pneumoniae, which had 75% susceptibility to meropenem. Knowledge of microbiological profile and susceptibility patterns of patients with DFIs is useful to guide empirical therapy. MDPI 2022-08-19 /pmc/articles/PMC9405336/ /pubmed/36009994 http://dx.doi.org/10.3390/antibiotics11081125 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Palomo, Amanda Thurler
Pires, Ana Paula Maia
Matielo, Marcelo Fernando
de Athayde Soares, Rafael
Pecego, Christiano
Sacilotto, Roberto
de Paula, Alexandre Inacio
Hosino, Nair
de Melo Gamba, Cristiano
Fonseca, Cibele Lefreve
Paraskevopoulos, Daniela K. S.
Yamaguti, Augusto
de Mendonça, João Silva
Costa, Silvia Figueiredo
Guimarães, Thaís
Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil
title Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil
title_full Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil
title_fullStr Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil
title_full_unstemmed Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil
title_short Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil
title_sort microbiology of diabetic foot infections in a tertiary care hospital in são paulo, brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405336/
https://www.ncbi.nlm.nih.gov/pubmed/36009994
http://dx.doi.org/10.3390/antibiotics11081125
work_keys_str_mv AT palomoamandathurler microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT piresanapaulamaia microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT matielomarcelofernando microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT deathaydesoaresrafael microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT pecegochristiano microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT sacilottoroberto microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT depaulaalexandreinacio microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT hosinonair microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT demelogambacristiano microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT fonsecacibelelefreve microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT paraskevopoulosdanielaks microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT yamagutiaugusto microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT demendoncajoaosilva microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT costasilviafigueiredo microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil
AT guimaraesthais microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil