Cargando…
Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil
Diabetic foot infections (DFIs) are one of the causes of hospitalization in diabetic patients and, when this occurs, empirical antibiotic therapy is necessary. We have conducted a retrospective study of patients with DFI that required hospitalization to evaluate microbiologic profile and the suscept...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405336/ https://www.ncbi.nlm.nih.gov/pubmed/36009994 http://dx.doi.org/10.3390/antibiotics11081125 |
_version_ | 1784773855973212160 |
---|---|
author | Palomo, Amanda Thurler Pires, Ana Paula Maia Matielo, Marcelo Fernando de Athayde Soares, Rafael Pecego, Christiano Sacilotto, Roberto de Paula, Alexandre Inacio Hosino, Nair de Melo Gamba, Cristiano Fonseca, Cibele Lefreve Paraskevopoulos, Daniela K. S. Yamaguti, Augusto de Mendonça, João Silva Costa, Silvia Figueiredo Guimarães, Thaís |
author_facet | Palomo, Amanda Thurler Pires, Ana Paula Maia Matielo, Marcelo Fernando de Athayde Soares, Rafael Pecego, Christiano Sacilotto, Roberto de Paula, Alexandre Inacio Hosino, Nair de Melo Gamba, Cristiano Fonseca, Cibele Lefreve Paraskevopoulos, Daniela K. S. Yamaguti, Augusto de Mendonça, João Silva Costa, Silvia Figueiredo Guimarães, Thaís |
author_sort | Palomo, Amanda Thurler |
collection | PubMed |
description | Diabetic foot infections (DFIs) are one of the causes of hospitalization in diabetic patients and, when this occurs, empirical antibiotic therapy is necessary. We have conducted a retrospective study of patients with DFI that required hospitalization to evaluate microbiologic profile and the susceptibility pattern of these infections. We evaluated 320 patients, of which 223 (69.7%) were male with a media age of 71 years with 276 isolates. Gram-positive bacteria were responsible for 188 (68.1%) of the isolates, while Gram-negative bacilli were responsible for 88 (31.9%). E. faecalis was the most prevalent pathogen, followed by S. aureus and coagulase negative Staphylococci. Among Gram-negative pathogens, P. aeruginosa was the most prevalent agent. Regarding the susceptibility profile, we found ampicillin-sensitive enterococci in 89% of the cases, oxacillin-sensitive S. aureus in 47%, but in coagulase-negative staphylococci, oxacillin was sensible only in 20%. The susceptibility profile of Gram-negatives was very good with 76% susceptibility of P. aeruginosa to ceftazidime and meropenem. The other prevalent Enterobacterales had great susceptibility to ceftazidime, piperacillin-tazobactam and 100% susceptibility to meropenem, with the exception of K. pneumoniae, which had 75% susceptibility to meropenem. Knowledge of microbiological profile and susceptibility patterns of patients with DFIs is useful to guide empirical therapy. |
format | Online Article Text |
id | pubmed-9405336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94053362022-08-26 Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil Palomo, Amanda Thurler Pires, Ana Paula Maia Matielo, Marcelo Fernando de Athayde Soares, Rafael Pecego, Christiano Sacilotto, Roberto de Paula, Alexandre Inacio Hosino, Nair de Melo Gamba, Cristiano Fonseca, Cibele Lefreve Paraskevopoulos, Daniela K. S. Yamaguti, Augusto de Mendonça, João Silva Costa, Silvia Figueiredo Guimarães, Thaís Antibiotics (Basel) Article Diabetic foot infections (DFIs) are one of the causes of hospitalization in diabetic patients and, when this occurs, empirical antibiotic therapy is necessary. We have conducted a retrospective study of patients with DFI that required hospitalization to evaluate microbiologic profile and the susceptibility pattern of these infections. We evaluated 320 patients, of which 223 (69.7%) were male with a media age of 71 years with 276 isolates. Gram-positive bacteria were responsible for 188 (68.1%) of the isolates, while Gram-negative bacilli were responsible for 88 (31.9%). E. faecalis was the most prevalent pathogen, followed by S. aureus and coagulase negative Staphylococci. Among Gram-negative pathogens, P. aeruginosa was the most prevalent agent. Regarding the susceptibility profile, we found ampicillin-sensitive enterococci in 89% of the cases, oxacillin-sensitive S. aureus in 47%, but in coagulase-negative staphylococci, oxacillin was sensible only in 20%. The susceptibility profile of Gram-negatives was very good with 76% susceptibility of P. aeruginosa to ceftazidime and meropenem. The other prevalent Enterobacterales had great susceptibility to ceftazidime, piperacillin-tazobactam and 100% susceptibility to meropenem, with the exception of K. pneumoniae, which had 75% susceptibility to meropenem. Knowledge of microbiological profile and susceptibility patterns of patients with DFIs is useful to guide empirical therapy. MDPI 2022-08-19 /pmc/articles/PMC9405336/ /pubmed/36009994 http://dx.doi.org/10.3390/antibiotics11081125 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Palomo, Amanda Thurler Pires, Ana Paula Maia Matielo, Marcelo Fernando de Athayde Soares, Rafael Pecego, Christiano Sacilotto, Roberto de Paula, Alexandre Inacio Hosino, Nair de Melo Gamba, Cristiano Fonseca, Cibele Lefreve Paraskevopoulos, Daniela K. S. Yamaguti, Augusto de Mendonça, João Silva Costa, Silvia Figueiredo Guimarães, Thaís Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil |
title | Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil |
title_full | Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil |
title_fullStr | Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil |
title_full_unstemmed | Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil |
title_short | Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil |
title_sort | microbiology of diabetic foot infections in a tertiary care hospital in são paulo, brazil |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405336/ https://www.ncbi.nlm.nih.gov/pubmed/36009994 http://dx.doi.org/10.3390/antibiotics11081125 |
work_keys_str_mv | AT palomoamandathurler microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT piresanapaulamaia microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT matielomarcelofernando microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT deathaydesoaresrafael microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT pecegochristiano microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT sacilottoroberto microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT depaulaalexandreinacio microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT hosinonair microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT demelogambacristiano microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT fonsecacibelelefreve microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT paraskevopoulosdanielaks microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT yamagutiaugusto microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT demendoncajoaosilva microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT costasilviafigueiredo microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil AT guimaraesthais microbiologyofdiabeticfootinfectionsinatertiarycarehospitalinsaopaulobrazil |