Enhanced immunogenicity of a positively supercharged archaeon thioredoxin scaffold as a cell-penetrating antigen carrier for peptide vaccines

Polycationic resurfaced proteins hold great promise as cell-penetrating bioreagents but their use as carriers for the intracellular delivery of peptide immuno-epitopes has not thus far been explored. Here, we report on the construction and functional characterization of a positively supercharged der...

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Detalles Bibliográficos
Autores principales: Cavazzini, Davide, Spagnoli, Gloria, Mariz, Filipe Colaco, Reggiani, Filippo, Maggi, Stefano, Franceschi, Valentina, Donofrio, Gaetano, Müller, Martin, Bolchi, Angelo, Ottonello, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405434/
https://www.ncbi.nlm.nih.gov/pubmed/36032169
http://dx.doi.org/10.3389/fimmu.2022.958123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405434/
https://www.ncbi.nlm.nih.gov/pubmed/36032169
http://dx.doi.org/10.3389/fimmu.2022.958123

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