Glycolysis and the Pentose Phosphate Pathway Promote LPS-Induced NOX2 Oxidase- and IFN-β-Dependent Inflammation in Macrophages

Macrophages undergo a metabolic switch from oxidative phosphorylation to glycolysis when exposed to gram-negative bacterial lipopolysaccharide (LPS), which modulates antibacterial host defence mechanisms. Here, we show that LPS treatment of macrophages increased the classical oxidative burst respons...

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Detalles Bibliográficos
Autores principales: Erlich, Jonathan R., To, Eunice E., Luong, Raymond, Liong, Felicia, Liong, Stella, Oseghale, Osezua, Miles, Mark A., Bozinovski, Steven, Brooks, Robert D., Vlahos, Ross, Chan, Stanley, O’Leary, John J., Brooks, Doug A., Selemidis, Stavros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405479/
https://www.ncbi.nlm.nih.gov/pubmed/36009206
http://dx.doi.org/10.3390/antiox11081488

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