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Regulation of Insulin Clearance by Non-Esterified Fatty Acids
Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in the liver, a major site of insulin clearance....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405499/ https://www.ncbi.nlm.nih.gov/pubmed/36009446 http://dx.doi.org/10.3390/biomedicines10081899 |
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author | Najjar, Sonia M. Abdolahipour, Raziyeh Ghadieh, Hilda E. Jahromi, Marziyeh Salehi Najjar, John A. Abuamreh, Basil A. M. Zaidi, Sobia Kumarasamy, Sivarajan Muturi, Harrison T. |
author_facet | Najjar, Sonia M. Abdolahipour, Raziyeh Ghadieh, Hilda E. Jahromi, Marziyeh Salehi Najjar, John A. Abuamreh, Basil A. M. Zaidi, Sobia Kumarasamy, Sivarajan Muturi, Harrison T. |
author_sort | Najjar, Sonia M. |
collection | PubMed |
description | Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in the liver, a major site of insulin clearance. This causes a reduction in insulin clearance as a compensatory mechanism to insulin resistance in obesity. On the other hand, reduced insulin clearance in the liver can cause chronic hyperinsulinemia, followed by downregulation of insulin receptor and insulin resistance. Delineating the cause–effect relationship between reduced insulin clearance and insulin resistance has been complicated by the fact that insulin action and clearance are mechanistically linked to insulin binding to its receptors. This review discusses how NEFA mobilization contributes to the reciprocal relationship between insulin resistance and reduced hepatic insulin clearance, and how this may be implicated in the pathogenesis of non-alcoholic fatty liver disease. |
format | Online Article Text |
id | pubmed-9405499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94054992022-08-26 Regulation of Insulin Clearance by Non-Esterified Fatty Acids Najjar, Sonia M. Abdolahipour, Raziyeh Ghadieh, Hilda E. Jahromi, Marziyeh Salehi Najjar, John A. Abuamreh, Basil A. M. Zaidi, Sobia Kumarasamy, Sivarajan Muturi, Harrison T. Biomedicines Review Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in the liver, a major site of insulin clearance. This causes a reduction in insulin clearance as a compensatory mechanism to insulin resistance in obesity. On the other hand, reduced insulin clearance in the liver can cause chronic hyperinsulinemia, followed by downregulation of insulin receptor and insulin resistance. Delineating the cause–effect relationship between reduced insulin clearance and insulin resistance has been complicated by the fact that insulin action and clearance are mechanistically linked to insulin binding to its receptors. This review discusses how NEFA mobilization contributes to the reciprocal relationship between insulin resistance and reduced hepatic insulin clearance, and how this may be implicated in the pathogenesis of non-alcoholic fatty liver disease. MDPI 2022-08-05 /pmc/articles/PMC9405499/ /pubmed/36009446 http://dx.doi.org/10.3390/biomedicines10081899 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Najjar, Sonia M. Abdolahipour, Raziyeh Ghadieh, Hilda E. Jahromi, Marziyeh Salehi Najjar, John A. Abuamreh, Basil A. M. Zaidi, Sobia Kumarasamy, Sivarajan Muturi, Harrison T. Regulation of Insulin Clearance by Non-Esterified Fatty Acids |
title | Regulation of Insulin Clearance by Non-Esterified Fatty Acids |
title_full | Regulation of Insulin Clearance by Non-Esterified Fatty Acids |
title_fullStr | Regulation of Insulin Clearance by Non-Esterified Fatty Acids |
title_full_unstemmed | Regulation of Insulin Clearance by Non-Esterified Fatty Acids |
title_short | Regulation of Insulin Clearance by Non-Esterified Fatty Acids |
title_sort | regulation of insulin clearance by non-esterified fatty acids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405499/ https://www.ncbi.nlm.nih.gov/pubmed/36009446 http://dx.doi.org/10.3390/biomedicines10081899 |
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