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Regulation of Insulin Clearance by Non-Esterified Fatty Acids

Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in the liver, a major site of insulin clearance....

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Autores principales: Najjar, Sonia M., Abdolahipour, Raziyeh, Ghadieh, Hilda E., Jahromi, Marziyeh Salehi, Najjar, John A., Abuamreh, Basil A. M., Zaidi, Sobia, Kumarasamy, Sivarajan, Muturi, Harrison T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405499/
https://www.ncbi.nlm.nih.gov/pubmed/36009446
http://dx.doi.org/10.3390/biomedicines10081899
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author Najjar, Sonia M.
Abdolahipour, Raziyeh
Ghadieh, Hilda E.
Jahromi, Marziyeh Salehi
Najjar, John A.
Abuamreh, Basil A. M.
Zaidi, Sobia
Kumarasamy, Sivarajan
Muturi, Harrison T.
author_facet Najjar, Sonia M.
Abdolahipour, Raziyeh
Ghadieh, Hilda E.
Jahromi, Marziyeh Salehi
Najjar, John A.
Abuamreh, Basil A. M.
Zaidi, Sobia
Kumarasamy, Sivarajan
Muturi, Harrison T.
author_sort Najjar, Sonia M.
collection PubMed
description Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in the liver, a major site of insulin clearance. This causes a reduction in insulin clearance as a compensatory mechanism to insulin resistance in obesity. On the other hand, reduced insulin clearance in the liver can cause chronic hyperinsulinemia, followed by downregulation of insulin receptor and insulin resistance. Delineating the cause–effect relationship between reduced insulin clearance and insulin resistance has been complicated by the fact that insulin action and clearance are mechanistically linked to insulin binding to its receptors. This review discusses how NEFA mobilization contributes to the reciprocal relationship between insulin resistance and reduced hepatic insulin clearance, and how this may be implicated in the pathogenesis of non-alcoholic fatty liver disease.
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spelling pubmed-94054992022-08-26 Regulation of Insulin Clearance by Non-Esterified Fatty Acids Najjar, Sonia M. Abdolahipour, Raziyeh Ghadieh, Hilda E. Jahromi, Marziyeh Salehi Najjar, John A. Abuamreh, Basil A. M. Zaidi, Sobia Kumarasamy, Sivarajan Muturi, Harrison T. Biomedicines Review Insulin stores lipid in adipocytes and prevents lipolysis and the release of non-esterified fatty acids (NEFA). Excessive release of NEFA during sustained energy supply and increase in abdominal adiposity trigger systemic insulin resistance, including in the liver, a major site of insulin clearance. This causes a reduction in insulin clearance as a compensatory mechanism to insulin resistance in obesity. On the other hand, reduced insulin clearance in the liver can cause chronic hyperinsulinemia, followed by downregulation of insulin receptor and insulin resistance. Delineating the cause–effect relationship between reduced insulin clearance and insulin resistance has been complicated by the fact that insulin action and clearance are mechanistically linked to insulin binding to its receptors. This review discusses how NEFA mobilization contributes to the reciprocal relationship between insulin resistance and reduced hepatic insulin clearance, and how this may be implicated in the pathogenesis of non-alcoholic fatty liver disease. MDPI 2022-08-05 /pmc/articles/PMC9405499/ /pubmed/36009446 http://dx.doi.org/10.3390/biomedicines10081899 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Najjar, Sonia M.
Abdolahipour, Raziyeh
Ghadieh, Hilda E.
Jahromi, Marziyeh Salehi
Najjar, John A.
Abuamreh, Basil A. M.
Zaidi, Sobia
Kumarasamy, Sivarajan
Muturi, Harrison T.
Regulation of Insulin Clearance by Non-Esterified Fatty Acids
title Regulation of Insulin Clearance by Non-Esterified Fatty Acids
title_full Regulation of Insulin Clearance by Non-Esterified Fatty Acids
title_fullStr Regulation of Insulin Clearance by Non-Esterified Fatty Acids
title_full_unstemmed Regulation of Insulin Clearance by Non-Esterified Fatty Acids
title_short Regulation of Insulin Clearance by Non-Esterified Fatty Acids
title_sort regulation of insulin clearance by non-esterified fatty acids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405499/
https://www.ncbi.nlm.nih.gov/pubmed/36009446
http://dx.doi.org/10.3390/biomedicines10081899
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