Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in a Humanised Mouse Model

Introduction: immune-mediated necrotising myopathy (IMNM) is associated with pathogenic anti-signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, at least partly through activation of the classical pathway of the complement. We evaluated zilucoplan, an in...

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Detalles Bibliográficos
Autores principales: Julien, Sarah, Vadysirisack, Douangsone, Sayegh, Camil, Ragunathan, Sharan, Tang, Yalan, Briand, Emma, Carrette, Marion, Jean, Laetitia, Zoubairi, Rachid, Gondé, Henri, Benveniste, Olivier, Allenbach, Yves, Drouot, Laurent, Boyer, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405589/
https://www.ncbi.nlm.nih.gov/pubmed/36009583
http://dx.doi.org/10.3390/biomedicines10082036

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