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Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer

Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor...

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Detalles Bibliográficos
Autores principales: Wang, Tian, Chen, Yingying, Wang, Bo, Gao, Xiaofan, Wu, Mingfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405640/
https://www.ncbi.nlm.nih.gov/pubmed/36008937
http://dx.doi.org/10.3390/biom12081044
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author Wang, Tian
Chen, Yingying
Wang, Bo
Gao, Xiaofan
Wu, Mingfu
author_facet Wang, Tian
Chen, Yingying
Wang, Bo
Gao, Xiaofan
Wu, Mingfu
author_sort Wang, Tian
collection PubMed
description Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor elimination with a maximum preservation of normal tissue. Recently, second near-infrared region (NIR-II, 1000–1700 nm) fluorescence has shown great application potential in cancer theranostics due to its inherent advantages, such as great penetration capacity, minimal tissue absorption and scattering, and low autofluorescence. With the development of fluorescence imaging systems and fluorescent probes, tumor detection, margin definition, and individualized therapy can be achieved quickly, enabling an increasingly accurate diagnosis and treatment of cancer. Herein, this review introduces the role of NIR-II fluorescence imaging in cancer diagnosis and summarizes the representative applications of NIR-II image-guided treatment in cancer therapy. Ultimately, we discuss the present challenges and future perspectives on fluorescence imaging in the field of cancer theranostics and put forward our opinions on how to improve the accuracy and efficiency of cancer diagnosis and therapeutics.
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spelling pubmed-94056402022-08-26 Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer Wang, Tian Chen, Yingying Wang, Bo Gao, Xiaofan Wu, Mingfu Biomolecules Review Cancer continues to be one of the leading causes of death worldwide, and its incidence is on the rise. Although cancer diagnosis and therapy have advanced significantly in recent decades, it is still a challenge to achieve the accurate identification and localization of cancer and to complete tumor elimination with a maximum preservation of normal tissue. Recently, second near-infrared region (NIR-II, 1000–1700 nm) fluorescence has shown great application potential in cancer theranostics due to its inherent advantages, such as great penetration capacity, minimal tissue absorption and scattering, and low autofluorescence. With the development of fluorescence imaging systems and fluorescent probes, tumor detection, margin definition, and individualized therapy can be achieved quickly, enabling an increasingly accurate diagnosis and treatment of cancer. Herein, this review introduces the role of NIR-II fluorescence imaging in cancer diagnosis and summarizes the representative applications of NIR-II image-guided treatment in cancer therapy. Ultimately, we discuss the present challenges and future perspectives on fluorescence imaging in the field of cancer theranostics and put forward our opinions on how to improve the accuracy and efficiency of cancer diagnosis and therapeutics. MDPI 2022-07-28 /pmc/articles/PMC9405640/ /pubmed/36008937 http://dx.doi.org/10.3390/biom12081044 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Tian
Chen, Yingying
Wang, Bo
Gao, Xiaofan
Wu, Mingfu
Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
title Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
title_full Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
title_fullStr Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
title_full_unstemmed Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
title_short Recent Progress in Second Near-Infrared (NIR-II) Fluorescence Imaging in Cancer
title_sort recent progress in second near-infrared (nir-ii) fluorescence imaging in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405640/
https://www.ncbi.nlm.nih.gov/pubmed/36008937
http://dx.doi.org/10.3390/biom12081044
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