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Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia

Despite many available treatments, infants born to preeclamptic mothers continue to pose a serious clinical problem. The present study focuses on the evaluation of infants born to preeclamptic mothers for the occurrence of early-onset complications and attempts to link the clinical status of such in...

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Autores principales: Tousty, Piotr, Fraszczyk-Tousty, Magda, Ksel-Hryciów, Joanna, Łoniewska, Beata, Tousty, Joanna, Dzidek, Sylwia, Michalczyk, Kaja, Kwiatkowska, Ewa, Cymbaluk-Płoska, Aneta, Torbé, Andrzej, Kwiatkowski, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405653/
https://www.ncbi.nlm.nih.gov/pubmed/36009597
http://dx.doi.org/10.3390/biomedicines10082048
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author Tousty, Piotr
Fraszczyk-Tousty, Magda
Ksel-Hryciów, Joanna
Łoniewska, Beata
Tousty, Joanna
Dzidek, Sylwia
Michalczyk, Kaja
Kwiatkowska, Ewa
Cymbaluk-Płoska, Aneta
Torbé, Andrzej
Kwiatkowski, Sebastian
author_facet Tousty, Piotr
Fraszczyk-Tousty, Magda
Ksel-Hryciów, Joanna
Łoniewska, Beata
Tousty, Joanna
Dzidek, Sylwia
Michalczyk, Kaja
Kwiatkowska, Ewa
Cymbaluk-Płoska, Aneta
Torbé, Andrzej
Kwiatkowski, Sebastian
author_sort Tousty, Piotr
collection PubMed
description Despite many available treatments, infants born to preeclamptic mothers continue to pose a serious clinical problem. The present study focuses on the evaluation of infants born to preeclamptic mothers for the occurrence of early-onset complications and attempts to link the clinical status of such infants to the angiogenesis markers in maternal blood (sFlt-1, PlGF). The study included 77 newborns and their mothers diagnosed with preeclampsia. The infants were assessed for their perinatal outcomes, with an emphasis on adverse neonatal outcomes such us infections, RDS, PDA, NEC, IVH, ROP, or BPD during the hospitalization period. The cutoff point was established using the ROC curve for the occurrence of any adverse neonatal outcome and it was 204 for the sFlt-1/PlGF and 32 birth week with AOC 0.644 and 0.91, respectively. The newborns born to mothers with high ratios had longer hospitalization times and, generally, were more frequently diagnosed with any of the aforementioned adverse neonatal outcomes. Also, the neonates born prior to or at 32 wkGA with higher sFlt-1/PlGF ratios were statistically significantly more common to be diagnosed with any of the adverse neonatal outcomes compared to those with lower ratio born prior to or at 32 wkGA. The sFlt-1/PlGF ratio can be a useful tool in predicting short-term adverse neonatal outcomes. Infants born after a full 33 weeks gestation developed almost no severe neonatal complications. Appropriate screening and preventive healthcare for preeclampsia can contribute significantly to reducing the incidence of neonatal complications.
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spelling pubmed-94056532022-08-26 Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia Tousty, Piotr Fraszczyk-Tousty, Magda Ksel-Hryciów, Joanna Łoniewska, Beata Tousty, Joanna Dzidek, Sylwia Michalczyk, Kaja Kwiatkowska, Ewa Cymbaluk-Płoska, Aneta Torbé, Andrzej Kwiatkowski, Sebastian Biomedicines Article Despite many available treatments, infants born to preeclamptic mothers continue to pose a serious clinical problem. The present study focuses on the evaluation of infants born to preeclamptic mothers for the occurrence of early-onset complications and attempts to link the clinical status of such infants to the angiogenesis markers in maternal blood (sFlt-1, PlGF). The study included 77 newborns and their mothers diagnosed with preeclampsia. The infants were assessed for their perinatal outcomes, with an emphasis on adverse neonatal outcomes such us infections, RDS, PDA, NEC, IVH, ROP, or BPD during the hospitalization period. The cutoff point was established using the ROC curve for the occurrence of any adverse neonatal outcome and it was 204 for the sFlt-1/PlGF and 32 birth week with AOC 0.644 and 0.91, respectively. The newborns born to mothers with high ratios had longer hospitalization times and, generally, were more frequently diagnosed with any of the aforementioned adverse neonatal outcomes. Also, the neonates born prior to or at 32 wkGA with higher sFlt-1/PlGF ratios were statistically significantly more common to be diagnosed with any of the adverse neonatal outcomes compared to those with lower ratio born prior to or at 32 wkGA. The sFlt-1/PlGF ratio can be a useful tool in predicting short-term adverse neonatal outcomes. Infants born after a full 33 weeks gestation developed almost no severe neonatal complications. Appropriate screening and preventive healthcare for preeclampsia can contribute significantly to reducing the incidence of neonatal complications. MDPI 2022-08-22 /pmc/articles/PMC9405653/ /pubmed/36009597 http://dx.doi.org/10.3390/biomedicines10082048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tousty, Piotr
Fraszczyk-Tousty, Magda
Ksel-Hryciów, Joanna
Łoniewska, Beata
Tousty, Joanna
Dzidek, Sylwia
Michalczyk, Kaja
Kwiatkowska, Ewa
Cymbaluk-Płoska, Aneta
Torbé, Andrzej
Kwiatkowski, Sebastian
Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia
title Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia
title_full Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia
title_fullStr Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia
title_full_unstemmed Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia
title_short Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia
title_sort adverse neonatal outcome of pregnancies complicated by preeclampsia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405653/
https://www.ncbi.nlm.nih.gov/pubmed/36009597
http://dx.doi.org/10.3390/biomedicines10082048
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