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Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9

The prevalence of asthma is gradually increasing, and endangers human health. Many therapeutic agents have been developed to address this concern. Cinnamomum cassia (L.) J.Presl is a traditional herbal remedy in China, Japan, and Korea and used mainly to control common cold, cough, pneumonitis and f...

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Autores principales: Lim, Je-Oh, Kim, Yun Hee, Lee, Ik Soo, Kim, Woong-Il, Lee, Se-Jin, Pak, So-Won, Shin, In-Sik, Kim, Taesoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405665/
https://www.ncbi.nlm.nih.gov/pubmed/36034804
http://dx.doi.org/10.3389/fphar.2022.906916
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author Lim, Je-Oh
Kim, Yun Hee
Lee, Ik Soo
Kim, Woong-Il
Lee, Se-Jin
Pak, So-Won
Shin, In-Sik
Kim, Taesoo
author_facet Lim, Je-Oh
Kim, Yun Hee
Lee, Ik Soo
Kim, Woong-Il
Lee, Se-Jin
Pak, So-Won
Shin, In-Sik
Kim, Taesoo
author_sort Lim, Je-Oh
collection PubMed
description The prevalence of asthma is gradually increasing, and endangers human health. Many therapeutic agents have been developed to address this concern. Cinnamomum cassia (L.) J.Presl is a traditional herbal remedy in China, Japan, and Korea and used mainly to control common cold, cough, pneumonitis and fever in Donguibogam, a medical encyclopedia of Korea. Therefore, we investigated whether C. cassia (L.) J.Presl extract (CCE) confers protective effects on asthma model induced by ovalbumin (OVA). The animals were received intraperitoneal administration of OVA on day 1 and 14, and then subjected to OVA inhalation from day 21–23. They were orally treated CCE (30 and 100 mg/kg) from day 18–23. CCE administration decreased allergic responses, including airway hyperresponsiveness, eosinophilia, inflammatory cytokine production, and immunoglobulin E in OVA-exposed mice, along with the decline in inflammatory cell count and mucus secretion in respiratory tract. Additionally, CCE suppressed MAPK phosphorylation and MMP-9 expression in OVA-exposed mice. Overall, CCE treatment attenuated allergic responses induced by OVA exposure, which may be connected to the suppression of MAPK phosphorylation.
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spelling pubmed-94056652022-08-26 Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 Lim, Je-Oh Kim, Yun Hee Lee, Ik Soo Kim, Woong-Il Lee, Se-Jin Pak, So-Won Shin, In-Sik Kim, Taesoo Front Pharmacol Pharmacology The prevalence of asthma is gradually increasing, and endangers human health. Many therapeutic agents have been developed to address this concern. Cinnamomum cassia (L.) J.Presl is a traditional herbal remedy in China, Japan, and Korea and used mainly to control common cold, cough, pneumonitis and fever in Donguibogam, a medical encyclopedia of Korea. Therefore, we investigated whether C. cassia (L.) J.Presl extract (CCE) confers protective effects on asthma model induced by ovalbumin (OVA). The animals were received intraperitoneal administration of OVA on day 1 and 14, and then subjected to OVA inhalation from day 21–23. They were orally treated CCE (30 and 100 mg/kg) from day 18–23. CCE administration decreased allergic responses, including airway hyperresponsiveness, eosinophilia, inflammatory cytokine production, and immunoglobulin E in OVA-exposed mice, along with the decline in inflammatory cell count and mucus secretion in respiratory tract. Additionally, CCE suppressed MAPK phosphorylation and MMP-9 expression in OVA-exposed mice. Overall, CCE treatment attenuated allergic responses induced by OVA exposure, which may be connected to the suppression of MAPK phosphorylation. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9405665/ /pubmed/36034804 http://dx.doi.org/10.3389/fphar.2022.906916 Text en Copyright © 2022 Lim, Kim, Lee, Kim, Lee, Pak, Shin and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lim, Je-Oh
Kim, Yun Hee
Lee, Ik Soo
Kim, Woong-Il
Lee, Se-Jin
Pak, So-Won
Shin, In-Sik
Kim, Taesoo
Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
title Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
title_full Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
title_fullStr Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
title_full_unstemmed Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
title_short Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
title_sort cinnamomum cassia (l.) j.presl alleviates allergic responses in asthmatic mice via suppression of mapks and mmp-9
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405665/
https://www.ncbi.nlm.nih.gov/pubmed/36034804
http://dx.doi.org/10.3389/fphar.2022.906916
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