Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism

Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that r...

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Detalles Bibliográficos
Autores principales: Vaiman, Elena E., Shnayder, Natalia A., Khasanova, Aiperi K., Strelnik, Anna I., Gayduk, Arseny J., Al-Zamil, Mustafa, Sapronova, Margarita R., Zhukova, Natalia G., Smirnova, Daria A., Nasyrova, Regina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405702/
https://www.ncbi.nlm.nih.gov/pubmed/36009557
http://dx.doi.org/10.3390/biomedicines10082010
Descripción
Sumario:Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis.

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