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Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study

Considering virus-related and drug-induced immunocompromised status of critically ill COVID-19 patients, we hypothesize that these patients would more frequently develop ventilator-associated pneumonia (VAP) than patients with ARDS from other viral causes. We conducted a retrospective observational...

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Autores principales: Sarton, Benjamine, Grare, Marion, Vardon-Bounes, Fanny, Gaubert, Anna, Silva, Stein, Crognier, Laure, Riu, Béatrice, Seguin, Thierry, Georges, Bernard, Minville, Vincent, Ruiz, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405710/
https://www.ncbi.nlm.nih.gov/pubmed/36009500
http://dx.doi.org/10.3390/biomedicines10081952
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author Sarton, Benjamine
Grare, Marion
Vardon-Bounes, Fanny
Gaubert, Anna
Silva, Stein
Crognier, Laure
Riu, Béatrice
Seguin, Thierry
Georges, Bernard
Minville, Vincent
Ruiz, Stéphanie
author_facet Sarton, Benjamine
Grare, Marion
Vardon-Bounes, Fanny
Gaubert, Anna
Silva, Stein
Crognier, Laure
Riu, Béatrice
Seguin, Thierry
Georges, Bernard
Minville, Vincent
Ruiz, Stéphanie
author_sort Sarton, Benjamine
collection PubMed
description Considering virus-related and drug-induced immunocompromised status of critically ill COVID-19 patients, we hypothesize that these patients would more frequently develop ventilator-associated pneumonia (VAP) than patients with ARDS from other viral causes. We conducted a retrospective observational study in two intensive care units (ICUs) from France, between 2017 and 2020. We compared bacterial co-infection at ICU admission and throughout the disease course of two retrospective longitudinally sampled groups of critically ill patients, who were admitted to ICU for either H1N1 or SARS-CoV-2 respiratory infection and depicted moderate-to-severe ARDS criteria upon admission. Sixty patients in the H1N1 group and 65 in the COVID-19 group were included in the study. Bacterial co-infection at the endotracheal intubation time was diagnosed in 33% of H1N1 and 16% COVID-19 patients (p = 0.08). The VAP incidence per 100 days of mechanical ventilation was 3.4 (2.2–5.2) in the H1N1 group and 7.2 (5.3–9.6) in the COVID-19 group (p < 0.004). The HR to develop VAP was of 2.33 (1.34–4.04) higher in the COVID-19 group (p = 0.002). Ten percent of H1N1 patients and 30% of the COVID-19 patients had a second episode of VAP (p = 0.013). COVID-19 patients have fewer bacterial co-infections upon admission, but the incidence of secondary infections increased faster in this group compared to H1N1 patients.
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spelling pubmed-94057102022-08-26 Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study Sarton, Benjamine Grare, Marion Vardon-Bounes, Fanny Gaubert, Anna Silva, Stein Crognier, Laure Riu, Béatrice Seguin, Thierry Georges, Bernard Minville, Vincent Ruiz, Stéphanie Biomedicines Article Considering virus-related and drug-induced immunocompromised status of critically ill COVID-19 patients, we hypothesize that these patients would more frequently develop ventilator-associated pneumonia (VAP) than patients with ARDS from other viral causes. We conducted a retrospective observational study in two intensive care units (ICUs) from France, between 2017 and 2020. We compared bacterial co-infection at ICU admission and throughout the disease course of two retrospective longitudinally sampled groups of critically ill patients, who were admitted to ICU for either H1N1 or SARS-CoV-2 respiratory infection and depicted moderate-to-severe ARDS criteria upon admission. Sixty patients in the H1N1 group and 65 in the COVID-19 group were included in the study. Bacterial co-infection at the endotracheal intubation time was diagnosed in 33% of H1N1 and 16% COVID-19 patients (p = 0.08). The VAP incidence per 100 days of mechanical ventilation was 3.4 (2.2–5.2) in the H1N1 group and 7.2 (5.3–9.6) in the COVID-19 group (p < 0.004). The HR to develop VAP was of 2.33 (1.34–4.04) higher in the COVID-19 group (p = 0.002). Ten percent of H1N1 patients and 30% of the COVID-19 patients had a second episode of VAP (p = 0.013). COVID-19 patients have fewer bacterial co-infections upon admission, but the incidence of secondary infections increased faster in this group compared to H1N1 patients. MDPI 2022-08-11 /pmc/articles/PMC9405710/ /pubmed/36009500 http://dx.doi.org/10.3390/biomedicines10081952 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sarton, Benjamine
Grare, Marion
Vardon-Bounes, Fanny
Gaubert, Anna
Silva, Stein
Crognier, Laure
Riu, Béatrice
Seguin, Thierry
Georges, Bernard
Minville, Vincent
Ruiz, Stéphanie
Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study
title Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study
title_full Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study
title_fullStr Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study
title_full_unstemmed Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study
title_short Co-Infection and Ventilator-Associated Pneumonia in Critically Ill COVID-19 Patients Requiring Mechanical Ventilation: A Retrospective Cohort Study
title_sort co-infection and ventilator-associated pneumonia in critically ill covid-19 patients requiring mechanical ventilation: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405710/
https://www.ncbi.nlm.nih.gov/pubmed/36009500
http://dx.doi.org/10.3390/biomedicines10081952
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