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The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway

Tinnitus is defined as the phantom perception of sound. To date, there is no curative treatment, and contemporary treatments have failed to show beneficial outcomes. Deep brain stimulation has been suggested as a potential therapy for refractory tinnitus. However, the optimal target and stimulation...

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Autores principales: Almasabi, Faris, van Zwieten, Gusta, Alosaimi, Faisal, Smit, Jasper V., Temel, Yasin, Janssen, Marcus L. F., Jahanshahi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405782/
https://www.ncbi.nlm.nih.gov/pubmed/36009162
http://dx.doi.org/10.3390/brainsci12081099
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author Almasabi, Faris
van Zwieten, Gusta
Alosaimi, Faisal
Smit, Jasper V.
Temel, Yasin
Janssen, Marcus L. F.
Jahanshahi, Ali
author_facet Almasabi, Faris
van Zwieten, Gusta
Alosaimi, Faisal
Smit, Jasper V.
Temel, Yasin
Janssen, Marcus L. F.
Jahanshahi, Ali
author_sort Almasabi, Faris
collection PubMed
description Tinnitus is defined as the phantom perception of sound. To date, there is no curative treatment, and contemporary treatments have failed to show beneficial outcomes. Deep brain stimulation has been suggested as a potential therapy for refractory tinnitus. However, the optimal target and stimulation regimens remain to be defined. Herein, we investigated metabolic and neuronal activity changes using cytochrome C oxidase histochemistry and c-Fos immunohistochemistry in a noise trauma-induced rat model of tinnitus. We also assessed changes in neuronal activity following medial geniculate body (MGB) high-frequency stimulation (HFS). Metabolic activity was reduced in the primary auditory cortex, MGB and CA1 region of the hippocampus in noise-exposed rats. Additionally, c-Fos expression was increased in the primary auditory cortex of those animals. Furthermore, MGB-HFS enhanced c-Fos expression in the thalamic reticular nucleus. We concluded that noise trauma alters tissue activity in multiple brain areas including the auditory and limbic regions. MGB-HFS resulted in higher neuronal activity in the thalamic reticular nucleus. Given the prominent role of the auditory thalamus in tinnitus, these data provide more rationales towards targeting the MGB with HFS as a symptom management tool in tinnitus.
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spelling pubmed-94057822022-08-26 The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway Almasabi, Faris van Zwieten, Gusta Alosaimi, Faisal Smit, Jasper V. Temel, Yasin Janssen, Marcus L. F. Jahanshahi, Ali Brain Sci Article Tinnitus is defined as the phantom perception of sound. To date, there is no curative treatment, and contemporary treatments have failed to show beneficial outcomes. Deep brain stimulation has been suggested as a potential therapy for refractory tinnitus. However, the optimal target and stimulation regimens remain to be defined. Herein, we investigated metabolic and neuronal activity changes using cytochrome C oxidase histochemistry and c-Fos immunohistochemistry in a noise trauma-induced rat model of tinnitus. We also assessed changes in neuronal activity following medial geniculate body (MGB) high-frequency stimulation (HFS). Metabolic activity was reduced in the primary auditory cortex, MGB and CA1 region of the hippocampus in noise-exposed rats. Additionally, c-Fos expression was increased in the primary auditory cortex of those animals. Furthermore, MGB-HFS enhanced c-Fos expression in the thalamic reticular nucleus. We concluded that noise trauma alters tissue activity in multiple brain areas including the auditory and limbic regions. MGB-HFS resulted in higher neuronal activity in the thalamic reticular nucleus. Given the prominent role of the auditory thalamus in tinnitus, these data provide more rationales towards targeting the MGB with HFS as a symptom management tool in tinnitus. MDPI 2022-08-18 /pmc/articles/PMC9405782/ /pubmed/36009162 http://dx.doi.org/10.3390/brainsci12081099 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Almasabi, Faris
van Zwieten, Gusta
Alosaimi, Faisal
Smit, Jasper V.
Temel, Yasin
Janssen, Marcus L. F.
Jahanshahi, Ali
The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway
title The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway
title_full The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway
title_fullStr The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway
title_full_unstemmed The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway
title_short The Effect of Noise Trauma and Deep Brain Stimulation of the Medial Geniculate Body on Tissue Activity in the Auditory Pathway
title_sort effect of noise trauma and deep brain stimulation of the medial geniculate body on tissue activity in the auditory pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405782/
https://www.ncbi.nlm.nih.gov/pubmed/36009162
http://dx.doi.org/10.3390/brainsci12081099
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