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Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders

Increasing evidence strongly supports the key role of neuroinflammation in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Neuroinflammation may alter synaptic transmission contributing to the progression of...

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Autores principales: Assogna, Martina, Di Lorenzo, Francesco, Martorana, Alessandro, Koch, Giacomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405819/
https://www.ncbi.nlm.nih.gov/pubmed/36009055
http://dx.doi.org/10.3390/biom12081161
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author Assogna, Martina
Di Lorenzo, Francesco
Martorana, Alessandro
Koch, Giacomo
author_facet Assogna, Martina
Di Lorenzo, Francesco
Martorana, Alessandro
Koch, Giacomo
author_sort Assogna, Martina
collection PubMed
description Increasing evidence strongly supports the key role of neuroinflammation in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Neuroinflammation may alter synaptic transmission contributing to the progression of neurodegeneration, as largely documented in animal models and in patients’ studies. In the last few years, palmitoylethanolamide (PEA), an endogenous lipid mediator, and its new composite, which is a formulation constituted of PEA and the well-recognized antioxidant flavonoid luteolin (Lut) subjected to an ultra-micronization process (co-ultraPEALut), has been identified as a potential therapeutic agent in different disorders by exerting potential beneficial effects on neurodegeneration and neuroinflammation by modulating synaptic transmission. In this review, we will show the potential therapeutic effects of PEA in animal models and in patients affected by neurodegenerative disorders.
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spelling pubmed-94058192022-08-26 Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders Assogna, Martina Di Lorenzo, Francesco Martorana, Alessandro Koch, Giacomo Biomolecules Review Increasing evidence strongly supports the key role of neuroinflammation in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Neuroinflammation may alter synaptic transmission contributing to the progression of neurodegeneration, as largely documented in animal models and in patients’ studies. In the last few years, palmitoylethanolamide (PEA), an endogenous lipid mediator, and its new composite, which is a formulation constituted of PEA and the well-recognized antioxidant flavonoid luteolin (Lut) subjected to an ultra-micronization process (co-ultraPEALut), has been identified as a potential therapeutic agent in different disorders by exerting potential beneficial effects on neurodegeneration and neuroinflammation by modulating synaptic transmission. In this review, we will show the potential therapeutic effects of PEA in animal models and in patients affected by neurodegenerative disorders. MDPI 2022-08-22 /pmc/articles/PMC9405819/ /pubmed/36009055 http://dx.doi.org/10.3390/biom12081161 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Assogna, Martina
Di Lorenzo, Francesco
Martorana, Alessandro
Koch, Giacomo
Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
title Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
title_full Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
title_fullStr Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
title_full_unstemmed Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
title_short Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders
title_sort synaptic effects of palmitoylethanolamide in neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405819/
https://www.ncbi.nlm.nih.gov/pubmed/36009055
http://dx.doi.org/10.3390/biom12081161
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