Cargando…
Does Childhood Obesity Trigger Neuroinflammation?
Childhood obesity is constantly increasing around the world, and it has become a major public health issue. Considerable evidence indicates that overweight and obesity are important risk factors for the development of comorbidities such as cognitive decline, neuroinflammation and neurodegenerative d...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405861/ https://www.ncbi.nlm.nih.gov/pubmed/36009499 http://dx.doi.org/10.3390/biomedicines10081953 |
_version_ | 1784773981291675648 |
---|---|
author | Zingale, Valeria Domenica D’Angiolini, Simone Chiricosta, Luigi Calcaterra, Valeria Selvaggio, Giorgio Giuseppe Orlando Zuccotti, Gianvincenzo Destro, Francesca Pelizzo, Gloria Mazzon, Emanuela |
author_facet | Zingale, Valeria Domenica D’Angiolini, Simone Chiricosta, Luigi Calcaterra, Valeria Selvaggio, Giorgio Giuseppe Orlando Zuccotti, Gianvincenzo Destro, Francesca Pelizzo, Gloria Mazzon, Emanuela |
author_sort | Zingale, Valeria Domenica |
collection | PubMed |
description | Childhood obesity is constantly increasing around the world, and it has become a major public health issue. Considerable evidence indicates that overweight and obesity are important risk factors for the development of comorbidities such as cognitive decline, neuroinflammation and neurodegenerative diseases. It is known that during obesity, adipose tissue undergoes immune, metabolic and functional changes which could induce a neuroinflammatory response of the central nervous system (CNS). In this context, to inspect if obesity can start to trigger the neuroinflammation from a pediatric age, we surgically collected and analyzed adipose tissue from the periumbilical area of three obese children (AT-OB) and two normal-weight children (AT-Ctrl). We considered the transcriptomic profile of our samples to detect alterations in different biological processes that might be also involved in the inflammatory and neuroinflammatory response. Our results show alterations of lipid and fatty acids metabolism in AT-OB compared to the AT-Ctrl. We also observed an onset of inflammatory response in AT-OB. Interestingly, among the genes involved in neuroinflammation, GRN and SMO were upregulated, while IFNGR1 and SNCA were downregulated. Our study highlights that obesity may trigger inflammation and neuroinflammation from a pediatric age. |
format | Online Article Text |
id | pubmed-9405861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94058612022-08-26 Does Childhood Obesity Trigger Neuroinflammation? Zingale, Valeria Domenica D’Angiolini, Simone Chiricosta, Luigi Calcaterra, Valeria Selvaggio, Giorgio Giuseppe Orlando Zuccotti, Gianvincenzo Destro, Francesca Pelizzo, Gloria Mazzon, Emanuela Biomedicines Case Report Childhood obesity is constantly increasing around the world, and it has become a major public health issue. Considerable evidence indicates that overweight and obesity are important risk factors for the development of comorbidities such as cognitive decline, neuroinflammation and neurodegenerative diseases. It is known that during obesity, adipose tissue undergoes immune, metabolic and functional changes which could induce a neuroinflammatory response of the central nervous system (CNS). In this context, to inspect if obesity can start to trigger the neuroinflammation from a pediatric age, we surgically collected and analyzed adipose tissue from the periumbilical area of three obese children (AT-OB) and two normal-weight children (AT-Ctrl). We considered the transcriptomic profile of our samples to detect alterations in different biological processes that might be also involved in the inflammatory and neuroinflammatory response. Our results show alterations of lipid and fatty acids metabolism in AT-OB compared to the AT-Ctrl. We also observed an onset of inflammatory response in AT-OB. Interestingly, among the genes involved in neuroinflammation, GRN and SMO were upregulated, while IFNGR1 and SNCA were downregulated. Our study highlights that obesity may trigger inflammation and neuroinflammation from a pediatric age. MDPI 2022-08-11 /pmc/articles/PMC9405861/ /pubmed/36009499 http://dx.doi.org/10.3390/biomedicines10081953 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Zingale, Valeria Domenica D’Angiolini, Simone Chiricosta, Luigi Calcaterra, Valeria Selvaggio, Giorgio Giuseppe Orlando Zuccotti, Gianvincenzo Destro, Francesca Pelizzo, Gloria Mazzon, Emanuela Does Childhood Obesity Trigger Neuroinflammation? |
title | Does Childhood Obesity Trigger Neuroinflammation? |
title_full | Does Childhood Obesity Trigger Neuroinflammation? |
title_fullStr | Does Childhood Obesity Trigger Neuroinflammation? |
title_full_unstemmed | Does Childhood Obesity Trigger Neuroinflammation? |
title_short | Does Childhood Obesity Trigger Neuroinflammation? |
title_sort | does childhood obesity trigger neuroinflammation? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405861/ https://www.ncbi.nlm.nih.gov/pubmed/36009499 http://dx.doi.org/10.3390/biomedicines10081953 |
work_keys_str_mv | AT zingalevaleriadomenica doeschildhoodobesitytriggerneuroinflammation AT dangiolinisimone doeschildhoodobesitytriggerneuroinflammation AT chiricostaluigi doeschildhoodobesitytriggerneuroinflammation AT calcaterravaleria doeschildhoodobesitytriggerneuroinflammation AT selvaggiogiorgiogiuseppeorlando doeschildhoodobesitytriggerneuroinflammation AT zuccottigianvincenzo doeschildhoodobesitytriggerneuroinflammation AT destrofrancesca doeschildhoodobesitytriggerneuroinflammation AT pelizzogloria doeschildhoodobesitytriggerneuroinflammation AT mazzonemanuela doeschildhoodobesitytriggerneuroinflammation |