Cargando…

Plasmodium falciparum Nicotinamidase as A Novel Antimalarial Target

Inhibition of Plasmodium falciparum nicotinamidase could represent a potential antimalarial since parasites require nicotinic acid to successfully recycle nicotinamide to NAD(+), and importantly, humans lack this biosynthetic enzyme. Recently, mechanism-based inhibitors of nicotinamidase have been d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Donu, Dickson, Sharma, Chiranjeev, Cen, Yana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405955/ https://www.ncbi.nlm.nih.gov/pubmed/36009002 http://dx.doi.org/10.3390/biom12081109

Ejemplares similares

Emerging Role of Nicotinamide Riboside in Health and Diseases
por: Sharma, Chiranjeev, et al.
Publicado: (2022)

Multifunctional activity-based chemical probes for sirtuins
por: Sharma, Chiranjeev, et al.
Publicado: (2023)

Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target
por: Aroonsri, Aiyada, et al.
Publicado: (2019)

Converting the E. coli Isochorismatase Nicotinamidase into γ-Lactamase
por: Guo, Xiaoyan, et al.
Publicado: (2022)

Targeting the Plasmodium falciparum’s Thymidylate Monophosphate Kinase for the Identification of Novel Antimalarial Natural Compounds
por: Enninful, Kweku S., et al.
Publicado: (2022)

Targeting the Plasmodium falciparum proteome and organelles for potential antimalarial drug candidates
por: Abugri, James, et al.
Publicado: (2022)

Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents
por: van Schalkwyk, Donelly A, et al.
Publicado: (2017)

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance
por: Shahinas, Dea, et al.
Publicado: (2013)

Antimalarials increase vesicle pH in Plasmodium falciparum
Publicado: (1985)

Extrachromosomal DNA amplicons in antimalarial‐resistant Plasmodium falciparum
por: McDaniels, Jennifer M., et al.
Publicado: (2020)

Molecular Dynamics Simulations Suggest Ligand’s Binding to Nicotinamidase/Pyrazinamidase
por: Zhang, Ji-Long, et al.
Publicado: (2012)

Biochemical and Mutational Analysis of a Novel Nicotinamidase from Oceanobacillus iheyensis HTE831
por: Sánchez-Carrón, Guiomar, et al.
Publicado: (2013)

In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V
por: Ji, Xin, et al.
Publicado: (2022)

Pyrazoleamide compounds are potent antimalarials that target Na(+) homeostasis in intraerythrocytic Plasmodium falciparum
por: Vaidya, Akhil B., et al.
Publicado: (2014)

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
por: LaMonte, Gregory M., et al.
Publicado: (2020)

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets
por: Alam, Asrar
Publicado: (2014)

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
por: Verity, Robert, et al.
Publicado: (2020)

Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity
por: Sheen, Patricia, et al.
Publicado: (2020)

Distribution of Plasmodium falciparum K13 gene polymorphisms across transmission settings in Ghana
por: Dieng, Cheikh Cambel, et al.
Publicado: (2023)

Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China
por: Wang, Shan-Qing, et al.
Publicado: (2015)

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
por: Kreutzfeld, Oriana, et al.
Publicado: (2023)

Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
por: Huthmacher, Carola, et al.
Publicado: (2010)

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum
por: Krollenbrock, Alina, et al.
Publicado: (2021)

Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development
por: Ayanful-Torgby, Ruth, et al.
Publicado: (2021)

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial
por: Phyo, Aung Pyae, et al.
Publicado: (2016)

Human Sirtuin Regulators: The “Success” Stories
por: Curry, Alyson M., et al.
Publicado: (2021)

Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives
por: Marin-Menendez, Alejandro, et al.
Publicado: (2010)

Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum
por: Van Tyne, Daria, et al.
Publicado: (2011)

Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance
por: Carey, Maureen A., et al.
Publicado: (2017)

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
por: Sonoiki, Ebere, et al.
Publicado: (2017)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2018)

Genomic Epidemiology of Antimalarial Drug Resistance in Plasmodium falciparum in Southern China
por: Huang, Fang, et al.
Publicado: (2021)

Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells
por: Siddiqui, Ghizal, et al.
Publicado: (2022)

A Multi-Scale Computational Study on the Mechanism of Streptococcus pneumoniae Nicotinamidase (SpNic)
por: Ion, Bogdan F., et al.
Publicado: (2014)

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery
por: Pradhan, Anupam, et al.
Publicado: (2015)

Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition
por: Wang, Ping, et al.
Publicado: (2010)

Plasmodium falciparum merozoite invasion ligands, linked antimalarial resistance loci and ex vivo responses to antimalarials in The Gambia
por: Mbye, Haddijatou, et al.
Publicado: (2022)

Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates
por: Chirawurah, Jersley D., et al.
Publicado: (2017)

Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum
por: Brock, Aleisha R., et al.
Publicado: (2017)

Evaluating antimalarial efficacy by tracking glycolysis in Plasmodium falciparum using NMR spectroscopy
por: Shivapurkar, Rupali, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q7l9jlaupq2a3om6f8oni87kqs