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Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study

Contrast-medium-associated kidney injury is caused by the infusion of contrast media. Small vessel disease is significantly associated with various diseases, including simultaneous conditions of the kidney and brain, which are highly vulnerable to similar vascular damage and microvascular pathologie...

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Autores principales: Yu, Tung-Min, Chuang, Ya-Wen, Huang, Shih-Ting, Huang, Jin-An, Chen, Cheng-Hsu, Chung, Mu-Chi, Wu, Chun-Yi, Chang, Pi-Yi, Hsu, Chih-Cheng, Wu, Ming-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406096/
https://www.ncbi.nlm.nih.gov/pubmed/36009563
http://dx.doi.org/10.3390/biomedicines10082015
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author Yu, Tung-Min
Chuang, Ya-Wen
Huang, Shih-Ting
Huang, Jin-An
Chen, Cheng-Hsu
Chung, Mu-Chi
Wu, Chun-Yi
Chang, Pi-Yi
Hsu, Chih-Cheng
Wu, Ming-Ju
author_facet Yu, Tung-Min
Chuang, Ya-Wen
Huang, Shih-Ting
Huang, Jin-An
Chen, Cheng-Hsu
Chung, Mu-Chi
Wu, Chun-Yi
Chang, Pi-Yi
Hsu, Chih-Cheng
Wu, Ming-Ju
author_sort Yu, Tung-Min
collection PubMed
description Contrast-medium-associated kidney injury is caused by the infusion of contrast media. Small vessel disease is significantly associated with various diseases, including simultaneous conditions of the kidney and brain, which are highly vulnerable to similar vascular damage and microvascular pathologies. Data to investigate the adverse effect of contrast media on the brain remain extremely lacking. In this study, 11,332,616 NHI enrollees were selected and divided into two groups, exposed and not exposed to a contrast medium during the observation period, from which 1,461,684 pairs were selected for analyses through matching in terms of age, sex, comorbidities, and frequency of outpatient visits during the previous year. In total, 1,461,684 patients exposed to a contrast medium and 1,461,684 controls not exposed to one were enrolled. In multivariable Cox proportional hazard models, patients exposed to a contrast medium had an overall 2.09-fold higher risk of dementia. In multivariable-stratified analyses, the risk of Alzheimer’s disease was remarkably high in younger patients without any underlying comorbidity. This study is the first to discover that exposure to contrast media is significantly associated with the risk of dementia. A four-fold increased risk of vascular dementia was observed after exposure to a contrast medium. Further studies on the influence of exposure to contrast media on the brain are warranted.
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spelling pubmed-94060962022-08-26 Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study Yu, Tung-Min Chuang, Ya-Wen Huang, Shih-Ting Huang, Jin-An Chen, Cheng-Hsu Chung, Mu-Chi Wu, Chun-Yi Chang, Pi-Yi Hsu, Chih-Cheng Wu, Ming-Ju Biomedicines Article Contrast-medium-associated kidney injury is caused by the infusion of contrast media. Small vessel disease is significantly associated with various diseases, including simultaneous conditions of the kidney and brain, which are highly vulnerable to similar vascular damage and microvascular pathologies. Data to investigate the adverse effect of contrast media on the brain remain extremely lacking. In this study, 11,332,616 NHI enrollees were selected and divided into two groups, exposed and not exposed to a contrast medium during the observation period, from which 1,461,684 pairs were selected for analyses through matching in terms of age, sex, comorbidities, and frequency of outpatient visits during the previous year. In total, 1,461,684 patients exposed to a contrast medium and 1,461,684 controls not exposed to one were enrolled. In multivariable Cox proportional hazard models, patients exposed to a contrast medium had an overall 2.09-fold higher risk of dementia. In multivariable-stratified analyses, the risk of Alzheimer’s disease was remarkably high in younger patients without any underlying comorbidity. This study is the first to discover that exposure to contrast media is significantly associated with the risk of dementia. A four-fold increased risk of vascular dementia was observed after exposure to a contrast medium. Further studies on the influence of exposure to contrast media on the brain are warranted. MDPI 2022-08-19 /pmc/articles/PMC9406096/ /pubmed/36009563 http://dx.doi.org/10.3390/biomedicines10082015 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Tung-Min
Chuang, Ya-Wen
Huang, Shih-Ting
Huang, Jin-An
Chen, Cheng-Hsu
Chung, Mu-Chi
Wu, Chun-Yi
Chang, Pi-Yi
Hsu, Chih-Cheng
Wu, Ming-Ju
Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study
title Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study
title_full Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study
title_fullStr Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study
title_full_unstemmed Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study
title_short Risk of Dementia after Exposure to Contrast Media: A Nationwide, Population-Based Cohort Study
title_sort risk of dementia after exposure to contrast media: a nationwide, population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406096/
https://www.ncbi.nlm.nih.gov/pubmed/36009563
http://dx.doi.org/10.3390/biomedicines10082015
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