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In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons

Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ capture Aβ and its precursor proteins (i.e., APP and...

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Detalles Bibliográficos
Autores principales: McKendell, Alec K., Houser, Mei C. Q., Mitchell, Shane P. C., Wolfe, Michael S., Berezovska, Oksana, Maesako, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406119/
https://www.ncbi.nlm.nih.gov/pubmed/36005059
http://dx.doi.org/10.3390/bios12080663