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Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis
Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients. This study aims to analyze serum irisin levels in patients with chronic plaque psoriasis, to compare t...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406124/ https://www.ncbi.nlm.nih.gov/pubmed/36008990 http://dx.doi.org/10.3390/biom12081096 |
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author | Ambrogio, Francesca Sanesi, Lorenzo Oranger, Angela Barlusconi, Chiara Dicarlo, Manuela Pignataro, Patrizia Zerlotin, Roberta Romita, Paolo Favoino, Elvira Cazzato, Gerardo Cassano, Nicoletta Vena, Gino Antonio Foti, Caterina Grano, Maria |
author_facet | Ambrogio, Francesca Sanesi, Lorenzo Oranger, Angela Barlusconi, Chiara Dicarlo, Manuela Pignataro, Patrizia Zerlotin, Roberta Romita, Paolo Favoino, Elvira Cazzato, Gerardo Cassano, Nicoletta Vena, Gino Antonio Foti, Caterina Grano, Maria |
author_sort | Ambrogio, Francesca |
collection | PubMed |
description | Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients. This study aims to analyze serum irisin levels in patients with chronic plaque psoriasis, to compare them with values in controls, and to assess whether concentration of circulating irisin correlates with the severity of psoriasis, calculated by means of Psoriasis Area and Severity Index (PASI). We enrolled 46 patients with chronic plaque psoriasis; the control group included 46 sex- and age-matched subjects without any skin or systemic diseases. Serum irisin levels were measured by competitive enzyme linked immunosorbent assay. Our results showed a non-significant increase in serum irisin concentration in psoriatic patients compared to controls. A negative non-linear correlation between PASI and irisin levels was detected in psoriatic patients. Indeed, dividing patients according to psoriasis severity, the negative association between irisin and PASI was stronger in patients with mild psoriasis than in patients with higher PASI scores. Several control variables we tested showed no significant impact on serum irisin. However, erythrocyte sedimentation rate in the normal range was associated with significantly higher irisin levels in psoriatic patients. In conclusion, although irisin levels were not significantly different between controls and psoriatic patients, irisin was found to be negatively associated with psoriasis severity, especially in subjects with low PASI scores; however, further studies are needed to clarify the role of irisin in subjects with psoriasis. |
format | Online Article Text |
id | pubmed-9406124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94061242022-08-26 Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis Ambrogio, Francesca Sanesi, Lorenzo Oranger, Angela Barlusconi, Chiara Dicarlo, Manuela Pignataro, Patrizia Zerlotin, Roberta Romita, Paolo Favoino, Elvira Cazzato, Gerardo Cassano, Nicoletta Vena, Gino Antonio Foti, Caterina Grano, Maria Biomolecules Article Irisin is an adipo-myokine, mainly synthetized in skeletal muscles and adipose tissues, that is involved in multiple processes. Only a few studies have evaluated serum irisin in psoriatic patients. This study aims to analyze serum irisin levels in patients with chronic plaque psoriasis, to compare them with values in controls, and to assess whether concentration of circulating irisin correlates with the severity of psoriasis, calculated by means of Psoriasis Area and Severity Index (PASI). We enrolled 46 patients with chronic plaque psoriasis; the control group included 46 sex- and age-matched subjects without any skin or systemic diseases. Serum irisin levels were measured by competitive enzyme linked immunosorbent assay. Our results showed a non-significant increase in serum irisin concentration in psoriatic patients compared to controls. A negative non-linear correlation between PASI and irisin levels was detected in psoriatic patients. Indeed, dividing patients according to psoriasis severity, the negative association between irisin and PASI was stronger in patients with mild psoriasis than in patients with higher PASI scores. Several control variables we tested showed no significant impact on serum irisin. However, erythrocyte sedimentation rate in the normal range was associated with significantly higher irisin levels in psoriatic patients. In conclusion, although irisin levels were not significantly different between controls and psoriatic patients, irisin was found to be negatively associated with psoriasis severity, especially in subjects with low PASI scores; however, further studies are needed to clarify the role of irisin in subjects with psoriasis. MDPI 2022-08-10 /pmc/articles/PMC9406124/ /pubmed/36008990 http://dx.doi.org/10.3390/biom12081096 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ambrogio, Francesca Sanesi, Lorenzo Oranger, Angela Barlusconi, Chiara Dicarlo, Manuela Pignataro, Patrizia Zerlotin, Roberta Romita, Paolo Favoino, Elvira Cazzato, Gerardo Cassano, Nicoletta Vena, Gino Antonio Foti, Caterina Grano, Maria Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis |
title | Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis |
title_full | Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis |
title_fullStr | Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis |
title_full_unstemmed | Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis |
title_short | Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis |
title_sort | circulating irisin levels in patients with chronic plaque psoriasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406124/ https://www.ncbi.nlm.nih.gov/pubmed/36008990 http://dx.doi.org/10.3390/biom12081096 |
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