Characterisation of an Atrx Conditional Knockout Mouse Model: Atrx Loss Causes Endocrine Dysfunction Rather Than Pancreatic Neuroendocrine Tumour

SIMPLE SUMMARY: ATRX and DAXX mutations occur in 30–40% of pancreatic neuroendocrine tumours (PanNETs), and there are no reports in the literature of any genetically engineered mouse model (GEMM) evaluating the effect of Atrx disruption as a putative driver event on PanNET initiation. We created a n...

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Detalles Bibliográficos
Autores principales: Gaspar, Tiago Bordeira, Macedo, Sofia, Sá, Ana, Soares, Mariana Alves, Rodrigues, Daniela Ferreira, Sousa, Mafalda, Mendes, Nuno, Martins, Rui Sousa, Cardoso, Luís, Borges, Inês, Canberk, Sule, Gärtner, Fátima, Miranda-Alves, Leandro, Sobrinho-Simões, Manuel, Lopes, José Manuel, Soares, Paula, Vinagre, João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406167/
https://www.ncbi.nlm.nih.gov/pubmed/36010860
http://dx.doi.org/10.3390/cancers14163865

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