Cargando…

A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)

The precise control of target particles (20 µm) at different inclination angles θ(i) is achieved by combining a perturbed asymmetric sheathless Y-type microchannel and a digital transducer (IDT). The offset single-row micropillar array with the buffer area can not only concentrate large and small pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Duan, Junping, Ji, Miaomiao, Zhang, Binzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406206/
https://www.ncbi.nlm.nih.gov/pubmed/36005007
http://dx.doi.org/10.3390/bios12080611
_version_ 1784774065838358528
author Duan, Junping
Ji, Miaomiao
Zhang, Binzhen
author_facet Duan, Junping
Ji, Miaomiao
Zhang, Binzhen
author_sort Duan, Junping
collection PubMed
description The precise control of target particles (20 µm) at different inclination angles θ(i) is achieved by combining a perturbed asymmetric sheathless Y-type microchannel and a digital transducer (IDT). The offset single-row micropillar array with the buffer area can not only concentrate large and small particles in a fixed region of the flow channel, but also avoid the large deflection of some small particles at the end of the array. The addition of the buffer area can effectively improve the separation purity of the chip. By exploring the manufacturing process of the microchannel substrate, an adjustable tilted-angle scheme is proposed. The use of ataTSAW makes the acoustic field area in the microchannel have no corner effect region. Through experiments, when the signal source frequency was 33.6 MHz, and the flow rate was 20 µL/min, our designed chip could capture 20 µm particles when θ(i) = 5°. The deflection of 20 µm particles can be realized when θ(i) = 15°–45°. The precise dynamic separation of 20 µm particles can be achieved when θ(i) = 25°–45°, and the separation purity and efficiency were 97% and 100%, respectively.
format Online
Article
Text
id pubmed-9406206
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94062062022-08-26 A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) Duan, Junping Ji, Miaomiao Zhang, Binzhen Biosensors (Basel) Article The precise control of target particles (20 µm) at different inclination angles θ(i) is achieved by combining a perturbed asymmetric sheathless Y-type microchannel and a digital transducer (IDT). The offset single-row micropillar array with the buffer area can not only concentrate large and small particles in a fixed region of the flow channel, but also avoid the large deflection of some small particles at the end of the array. The addition of the buffer area can effectively improve the separation purity of the chip. By exploring the manufacturing process of the microchannel substrate, an adjustable tilted-angle scheme is proposed. The use of ataTSAW makes the acoustic field area in the microchannel have no corner effect region. Through experiments, when the signal source frequency was 33.6 MHz, and the flow rate was 20 µL/min, our designed chip could capture 20 µm particles when θ(i) = 5°. The deflection of 20 µm particles can be realized when θ(i) = 15°–45°. The precise dynamic separation of 20 µm particles can be achieved when θ(i) = 25°–45°, and the separation purity and efficiency were 97% and 100%, respectively. MDPI 2022-08-07 /pmc/articles/PMC9406206/ /pubmed/36005007 http://dx.doi.org/10.3390/bios12080611 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duan, Junping
Ji, Miaomiao
Zhang, Binzhen
A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)
title A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)
title_full A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)
title_fullStr A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)
title_full_unstemmed A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)
title_short A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)
title_sort perturbed asymmetrical y-typesheathless chip for particle control based on adjustable tilted-angle traveling surface acoustic waves (atatsaws)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406206/
https://www.ncbi.nlm.nih.gov/pubmed/36005007
http://dx.doi.org/10.3390/bios12080611
work_keys_str_mv AT duanjunping aperturbedasymmetricalytypesheathlesschipforparticlecontrolbasedonadjustabletiltedangletravelingsurfaceacousticwavesatatsaws
AT jimiaomiao aperturbedasymmetricalytypesheathlesschipforparticlecontrolbasedonadjustabletiltedangletravelingsurfaceacousticwavesatatsaws
AT zhangbinzhen aperturbedasymmetricalytypesheathlesschipforparticlecontrolbasedonadjustabletiltedangletravelingsurfaceacousticwavesatatsaws
AT duanjunping perturbedasymmetricalytypesheathlesschipforparticlecontrolbasedonadjustabletiltedangletravelingsurfaceacousticwavesatatsaws
AT jimiaomiao perturbedasymmetricalytypesheathlesschipforparticlecontrolbasedonadjustabletiltedangletravelingsurfaceacousticwavesatatsaws
AT zhangbinzhen perturbedasymmetricalytypesheathlesschipforparticlecontrolbasedonadjustabletiltedangletravelingsurfaceacousticwavesatatsaws