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A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs)
The precise control of target particles (20 µm) at different inclination angles θ(i) is achieved by combining a perturbed asymmetric sheathless Y-type microchannel and a digital transducer (IDT). The offset single-row micropillar array with the buffer area can not only concentrate large and small pa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406206/ https://www.ncbi.nlm.nih.gov/pubmed/36005007 http://dx.doi.org/10.3390/bios12080611 |
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author | Duan, Junping Ji, Miaomiao Zhang, Binzhen |
author_facet | Duan, Junping Ji, Miaomiao Zhang, Binzhen |
author_sort | Duan, Junping |
collection | PubMed |
description | The precise control of target particles (20 µm) at different inclination angles θ(i) is achieved by combining a perturbed asymmetric sheathless Y-type microchannel and a digital transducer (IDT). The offset single-row micropillar array with the buffer area can not only concentrate large and small particles in a fixed region of the flow channel, but also avoid the large deflection of some small particles at the end of the array. The addition of the buffer area can effectively improve the separation purity of the chip. By exploring the manufacturing process of the microchannel substrate, an adjustable tilted-angle scheme is proposed. The use of ataTSAW makes the acoustic field area in the microchannel have no corner effect region. Through experiments, when the signal source frequency was 33.6 MHz, and the flow rate was 20 µL/min, our designed chip could capture 20 µm particles when θ(i) = 5°. The deflection of 20 µm particles can be realized when θ(i) = 15°–45°. The precise dynamic separation of 20 µm particles can be achieved when θ(i) = 25°–45°, and the separation purity and efficiency were 97% and 100%, respectively. |
format | Online Article Text |
id | pubmed-9406206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94062062022-08-26 A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) Duan, Junping Ji, Miaomiao Zhang, Binzhen Biosensors (Basel) Article The precise control of target particles (20 µm) at different inclination angles θ(i) is achieved by combining a perturbed asymmetric sheathless Y-type microchannel and a digital transducer (IDT). The offset single-row micropillar array with the buffer area can not only concentrate large and small particles in a fixed region of the flow channel, but also avoid the large deflection of some small particles at the end of the array. The addition of the buffer area can effectively improve the separation purity of the chip. By exploring the manufacturing process of the microchannel substrate, an adjustable tilted-angle scheme is proposed. The use of ataTSAW makes the acoustic field area in the microchannel have no corner effect region. Through experiments, when the signal source frequency was 33.6 MHz, and the flow rate was 20 µL/min, our designed chip could capture 20 µm particles when θ(i) = 5°. The deflection of 20 µm particles can be realized when θ(i) = 15°–45°. The precise dynamic separation of 20 µm particles can be achieved when θ(i) = 25°–45°, and the separation purity and efficiency were 97% and 100%, respectively. MDPI 2022-08-07 /pmc/articles/PMC9406206/ /pubmed/36005007 http://dx.doi.org/10.3390/bios12080611 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Duan, Junping Ji, Miaomiao Zhang, Binzhen A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) |
title | A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) |
title_full | A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) |
title_fullStr | A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) |
title_full_unstemmed | A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) |
title_short | A Perturbed Asymmetrical Y-TypeSheathless Chip for Particle Control Based on Adjustable Tilted-Angle Traveling Surface Acoustic Waves (ataTSAWs) |
title_sort | perturbed asymmetrical y-typesheathless chip for particle control based on adjustable tilted-angle traveling surface acoustic waves (atatsaws) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406206/ https://www.ncbi.nlm.nih.gov/pubmed/36005007 http://dx.doi.org/10.3390/bios12080611 |
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