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Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review

Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly malignant tumor that mainly occurs in children under the age of 3 and has only been rarely described in adults. The fact that AT/RT patients have such a terrible prognosis is even more regrettable. Herein, we reported...

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Autores principales: Guo, Gengyin, Zhuang, Jianfeng, Zhang, Keke, Zhou, Zhizhen, Wang, Yanjun, Zhang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406290/
https://www.ncbi.nlm.nih.gov/pubmed/36034392
http://dx.doi.org/10.3389/fsurg.2022.864518
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author Guo, Gengyin
Zhuang, Jianfeng
Zhang, Keke
Zhou, Zhizhen
Wang, Yanjun
Zhang, Zhen
author_facet Guo, Gengyin
Zhuang, Jianfeng
Zhang, Keke
Zhou, Zhizhen
Wang, Yanjun
Zhang, Zhen
author_sort Guo, Gengyin
collection PubMed
description Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly malignant tumor that mainly occurs in children under the age of 3 and has only been rarely described in adults. The fact that AT/RT patients have such a terrible prognosis is even more regrettable. Herein, we reported two special cases of AT/RT, both of which were under 3 years. Symptoms at presentation included increased intracranial pressure and cerebellar symptoms such as headache, altered gait, and ataxia. As for the tumor location, one was infratentorial in the posterior fossa, and the other was the right lateral ventricle. Preoperative magnetic resonance imaging scans showed calcification and heterogeneous contrast enhancement in the lesions. The mass was excised surgically for the progression of symptoms. Postoperative pathologies of the tumors, combined with immunohistochemistry, revealed AT/RT. AT/RTs are often misdiagnosed as other types of brain tumors due to the lack of specific radiological features and other key characteristics. To improve awareness of AT/RT on the differential diagnosis of intracranial lesions among clinicians, we present this report and briefly summarize previous cases.
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spelling pubmed-94062902022-08-26 Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review Guo, Gengyin Zhuang, Jianfeng Zhang, Keke Zhou, Zhizhen Wang, Yanjun Zhang, Zhen Front Surg Surgery Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly malignant tumor that mainly occurs in children under the age of 3 and has only been rarely described in adults. The fact that AT/RT patients have such a terrible prognosis is even more regrettable. Herein, we reported two special cases of AT/RT, both of which were under 3 years. Symptoms at presentation included increased intracranial pressure and cerebellar symptoms such as headache, altered gait, and ataxia. As for the tumor location, one was infratentorial in the posterior fossa, and the other was the right lateral ventricle. Preoperative magnetic resonance imaging scans showed calcification and heterogeneous contrast enhancement in the lesions. The mass was excised surgically for the progression of symptoms. Postoperative pathologies of the tumors, combined with immunohistochemistry, revealed AT/RT. AT/RTs are often misdiagnosed as other types of brain tumors due to the lack of specific radiological features and other key characteristics. To improve awareness of AT/RT on the differential diagnosis of intracranial lesions among clinicians, we present this report and briefly summarize previous cases. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9406290/ /pubmed/36034392 http://dx.doi.org/10.3389/fsurg.2022.864518 Text en Copyright © 2022 Guo, Zhuang, Zhang, Zhou, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Guo, Gengyin
Zhuang, Jianfeng
Zhang, Keke
Zhou, Zhizhen
Wang, Yanjun
Zhang, Zhen
Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review
title Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review
title_full Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review
title_fullStr Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review
title_full_unstemmed Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review
title_short Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System in Children: Case Reports and Literature Review
title_sort atypical teratoid/rhabdoid tumor of the central nervous system in children: case reports and literature review
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406290/
https://www.ncbi.nlm.nih.gov/pubmed/36034392
http://dx.doi.org/10.3389/fsurg.2022.864518
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