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Low Copper Diet—A Therapeutic Option for Wilson Disease?

Wilson’s disease (WD) is an autosomal recessive inherited disease in which a pathological storage of copper in various organs is the mean pathophysiological mechanism. The therapy consists of drug therapy with chelating agents or zinc. For patients, nutrition is always an important issue. The aim of...

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Autores principales: Teufel-Schäfer, Ulrike, Forster, Christine, Schaefer, Nikolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406399/
https://www.ncbi.nlm.nih.gov/pubmed/36010023
http://dx.doi.org/10.3390/children9081132
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author Teufel-Schäfer, Ulrike
Forster, Christine
Schaefer, Nikolaus
author_facet Teufel-Schäfer, Ulrike
Forster, Christine
Schaefer, Nikolaus
author_sort Teufel-Schäfer, Ulrike
collection PubMed
description Wilson’s disease (WD) is an autosomal recessive inherited disease in which a pathological storage of copper in various organs is the mean pathophysiological mechanism. The therapy consists of drug therapy with chelating agents or zinc. For patients, nutrition is always an important issue. The aim of this review was to determine whether there are clear recommendations for a low copper diet for WD patients, or whether the essential trace element zinc plays a role? We were able to show that some of the foods with high copper content would have to be consumed in such large quantities that this is regularly not the case. Furthermore, there are also different absorption rates depending on the copper content. A lower copper intake only prevents the re-accumulation of copper. In summary, consistent adherence to drug therapy is more important than a strict diet. Only two foods should be consistently avoided: Liver and Shellfish.
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spelling pubmed-94063992022-08-26 Low Copper Diet—A Therapeutic Option for Wilson Disease? Teufel-Schäfer, Ulrike Forster, Christine Schaefer, Nikolaus Children (Basel) Review Wilson’s disease (WD) is an autosomal recessive inherited disease in which a pathological storage of copper in various organs is the mean pathophysiological mechanism. The therapy consists of drug therapy with chelating agents or zinc. For patients, nutrition is always an important issue. The aim of this review was to determine whether there are clear recommendations for a low copper diet for WD patients, or whether the essential trace element zinc plays a role? We were able to show that some of the foods with high copper content would have to be consumed in such large quantities that this is regularly not the case. Furthermore, there are also different absorption rates depending on the copper content. A lower copper intake only prevents the re-accumulation of copper. In summary, consistent adherence to drug therapy is more important than a strict diet. Only two foods should be consistently avoided: Liver and Shellfish. MDPI 2022-07-28 /pmc/articles/PMC9406399/ /pubmed/36010023 http://dx.doi.org/10.3390/children9081132 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Teufel-Schäfer, Ulrike
Forster, Christine
Schaefer, Nikolaus
Low Copper Diet—A Therapeutic Option for Wilson Disease?
title Low Copper Diet—A Therapeutic Option for Wilson Disease?
title_full Low Copper Diet—A Therapeutic Option for Wilson Disease?
title_fullStr Low Copper Diet—A Therapeutic Option for Wilson Disease?
title_full_unstemmed Low Copper Diet—A Therapeutic Option for Wilson Disease?
title_short Low Copper Diet—A Therapeutic Option for Wilson Disease?
title_sort low copper diet—a therapeutic option for wilson disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406399/
https://www.ncbi.nlm.nih.gov/pubmed/36010023
http://dx.doi.org/10.3390/children9081132
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