Cargando…

Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study

Better mechanisms of predicting prognoses in patients with metastatic breast cancer will improve the identification of patients for whom curative treatments may be the most effective. In this study, the prognostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((1...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Hojin, Cho, Arthur, Kang, Won Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406466/
https://www.ncbi.nlm.nih.gov/pubmed/36010160
http://dx.doi.org/10.3390/diagnostics12081809
_version_ 1784774128025206784
author Cho, Hojin
Cho, Arthur
Kang, Won Jun
author_facet Cho, Hojin
Cho, Arthur
Kang, Won Jun
author_sort Cho, Hojin
collection PubMed
description Better mechanisms of predicting prognoses in patients with metastatic breast cancer will improve the identification of patients for whom curative treatments may be the most effective. In this study, the prognostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was assessed in patients with metastatic breast cancer. A retrospective analysis of women who underwent (18)F-FDG PET/CT for staging of newly diagnosed metastatic breast cancer was conducted. In each patient, the maximum standardized uptake value (SUV) and total lesion glycolysis (TLG) of primary tumors and regional lymph nodes were measured and analyzed for association with survival using the Cox proportional hazards regression model. From 346 consecutive patients, 32 with metastatic invasive ductal carcinoma of the breast were included in the study. The median duration of follow-up was 22.5 months. Disease progression occurred in 26 patients, and 11 patients died. When multivariate analyses with a stepwise forward regression were applied, only the maximum SUV and TLG of regional lymph nodes showed a significant correlation with progression-free survival and overall survival, respectively. This study demonstrates that increased (18)F-FDG uptake in regional lymph nodes is a strong independent predictor of survival in women with metastatic invasive ductal carcinoma of the breast.
format Online
Article
Text
id pubmed-9406466
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94064662022-08-26 Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study Cho, Hojin Cho, Arthur Kang, Won Jun Diagnostics (Basel) Article Better mechanisms of predicting prognoses in patients with metastatic breast cancer will improve the identification of patients for whom curative treatments may be the most effective. In this study, the prognostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was assessed in patients with metastatic breast cancer. A retrospective analysis of women who underwent (18)F-FDG PET/CT for staging of newly diagnosed metastatic breast cancer was conducted. In each patient, the maximum standardized uptake value (SUV) and total lesion glycolysis (TLG) of primary tumors and regional lymph nodes were measured and analyzed for association with survival using the Cox proportional hazards regression model. From 346 consecutive patients, 32 with metastatic invasive ductal carcinoma of the breast were included in the study. The median duration of follow-up was 22.5 months. Disease progression occurred in 26 patients, and 11 patients died. When multivariate analyses with a stepwise forward regression were applied, only the maximum SUV and TLG of regional lymph nodes showed a significant correlation with progression-free survival and overall survival, respectively. This study demonstrates that increased (18)F-FDG uptake in regional lymph nodes is a strong independent predictor of survival in women with metastatic invasive ductal carcinoma of the breast. MDPI 2022-07-27 /pmc/articles/PMC9406466/ /pubmed/36010160 http://dx.doi.org/10.3390/diagnostics12081809 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cho, Hojin
Cho, Arthur
Kang, Won Jun
Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study
title Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study
title_full Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study
title_fullStr Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study
title_full_unstemmed Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study
title_short Prognosis Associated with Glycolytic Activity in Regional Lymph Nodes of Patients with Previously Untreated Metastatic Breast Cancer: A Preliminary Study
title_sort prognosis associated with glycolytic activity in regional lymph nodes of patients with previously untreated metastatic breast cancer: a preliminary study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406466/
https://www.ncbi.nlm.nih.gov/pubmed/36010160
http://dx.doi.org/10.3390/diagnostics12081809
work_keys_str_mv AT chohojin prognosisassociatedwithglycolyticactivityinregionallymphnodesofpatientswithpreviouslyuntreatedmetastaticbreastcancerapreliminarystudy
AT choarthur prognosisassociatedwithglycolyticactivityinregionallymphnodesofpatientswithpreviouslyuntreatedmetastaticbreastcancerapreliminarystudy
AT kangwonjun prognosisassociatedwithglycolyticactivityinregionallymphnodesofpatientswithpreviouslyuntreatedmetastaticbreastcancerapreliminarystudy