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Epidemiology and Prevention of Renal Cell Carcinoma

SIMPLE SUMMARY: The incidence of renal cell carcinoma (RCC) rises globally with the highest rates in developed countries. This indicates not only the impact of advanced imaging, but also an increased prevalence of modifiable risk factors such as smoking, obesity, and hypertension. This review will s...

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Autores principales: Makino, Tomoyuki, Kadomoto, Suguru, Izumi, Kouji, Mizokami, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406474/
https://www.ncbi.nlm.nih.gov/pubmed/36011051
http://dx.doi.org/10.3390/cancers14164059
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author Makino, Tomoyuki
Kadomoto, Suguru
Izumi, Kouji
Mizokami, Atsushi
author_facet Makino, Tomoyuki
Kadomoto, Suguru
Izumi, Kouji
Mizokami, Atsushi
author_sort Makino, Tomoyuki
collection PubMed
description SIMPLE SUMMARY: The incidence of renal cell carcinoma (RCC) rises globally with the highest rates in developed countries. This indicates not only the impact of advanced imaging, but also an increased prevalence of modifiable risk factors such as smoking, obesity, and hypertension. This review will summarize the epidemiology and genetic variation of RCC, primary prevention-involving risk factors, and secondary prevention through early detection with a focus on biomarkers. ABSTRACT: With 400,000 diagnosed and 180,000 deaths in 2020, renal cell carcinoma (RCC) accounts for 2.4% of all cancer diagnoses worldwide. The highest disease burden developed countries, primarily in Europe and North America. Incidence is projected to increase in the future as more countries shift to Western lifestyles. Risk factors for RCC include fixed factors such as gender, age, and hereditary diseases, as well as intervening factors such as smoking, obesity, hypertension, diabetes, diet and alcohol, and occupational exposure. Intervening factors in primary prevention, understanding of congenital risk factors and the establishment of early diagnostic tools are important for RCC. This review will discuss RCC epidemiology, risk factors, and biomarkers involved in reducing incidence and improving survival.
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spelling pubmed-94064742022-08-26 Epidemiology and Prevention of Renal Cell Carcinoma Makino, Tomoyuki Kadomoto, Suguru Izumi, Kouji Mizokami, Atsushi Cancers (Basel) Review SIMPLE SUMMARY: The incidence of renal cell carcinoma (RCC) rises globally with the highest rates in developed countries. This indicates not only the impact of advanced imaging, but also an increased prevalence of modifiable risk factors such as smoking, obesity, and hypertension. This review will summarize the epidemiology and genetic variation of RCC, primary prevention-involving risk factors, and secondary prevention through early detection with a focus on biomarkers. ABSTRACT: With 400,000 diagnosed and 180,000 deaths in 2020, renal cell carcinoma (RCC) accounts for 2.4% of all cancer diagnoses worldwide. The highest disease burden developed countries, primarily in Europe and North America. Incidence is projected to increase in the future as more countries shift to Western lifestyles. Risk factors for RCC include fixed factors such as gender, age, and hereditary diseases, as well as intervening factors such as smoking, obesity, hypertension, diabetes, diet and alcohol, and occupational exposure. Intervening factors in primary prevention, understanding of congenital risk factors and the establishment of early diagnostic tools are important for RCC. This review will discuss RCC epidemiology, risk factors, and biomarkers involved in reducing incidence and improving survival. MDPI 2022-08-22 /pmc/articles/PMC9406474/ /pubmed/36011051 http://dx.doi.org/10.3390/cancers14164059 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Makino, Tomoyuki
Kadomoto, Suguru
Izumi, Kouji
Mizokami, Atsushi
Epidemiology and Prevention of Renal Cell Carcinoma
title Epidemiology and Prevention of Renal Cell Carcinoma
title_full Epidemiology and Prevention of Renal Cell Carcinoma
title_fullStr Epidemiology and Prevention of Renal Cell Carcinoma
title_full_unstemmed Epidemiology and Prevention of Renal Cell Carcinoma
title_short Epidemiology and Prevention of Renal Cell Carcinoma
title_sort epidemiology and prevention of renal cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406474/
https://www.ncbi.nlm.nih.gov/pubmed/36011051
http://dx.doi.org/10.3390/cancers14164059
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